Academic Journal
A comparative histological analysis of early and late graft dysfunction in different time zones following living donor liver transplantation
| العنوان: | A comparative histological analysis of early and late graft dysfunction in different time zones following living donor liver transplantation |
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| المؤلفون: | Archana Rastogi, Nayana Patil, Sphurti Srivastava, Gayatri Ramakrishna, Rakhi Maiwal, Guresh Kumar, Ashok K Choudhary, Seema Alam, Chhagan Bihari, Viniyendra Pamecha |
| المصدر: | Indian Journal of Pathology and Microbiology, Vol 65, Iss 4, Pp 802-808 (2022) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Pathology LCC:Microbiology |
| مصطلحات موضوعية: | acute rejection, chronic rejection, late acute rejection, liver allograft biopsy, spectrum, Pathology, RB1-214, Microbiology, QR1-502 |
| الوصف: | Background: Liver biopsy plays a crucial role in evaluating allograft dysfunction. Comprehensive analysis of the histological spectrum of complications, particularly rejection, in different time zones is lacking. Aim: To evaluate the histological spectrum of rejection, in four time zones, in a large Living donor liver transplant series. Patients and Methods: Retrospective analysis of 313 biopsies for the last 10 years of living donor liver transplantation (LDLT) recipients. 123 of which had rejection as diagnosis, were redistributed in four time zones [1-early ( 12) months] and were assessed for sixteen histological parameters. Results: Biopsies in time zone 1 (26.5%), 2 (20.7%), 3 (24.6%), and 4 (28.1%)] were nearly equal. Multiple coexistent complications existed in 12% of the cases. Rejection diagnosed in time zone groups: 1 = 22 (17.9%), 2 = 27 (22%), 3 = 36 (29.3%), and 4 = 38 (30.9%). Portal inflammation mixed type (P < 0.000), portal vein (P = 0.001) and hepatic vein endothelialitis (P < 0.000), portal eosinophils (P = 0.001), and lymphocytic bile duct damage (P = 0.01) were most pronounced in group 1. Perivenulitis without hepatic vein endothelialitis was observed (P = 0.03) in groups 3, whereas bile duct atypia (P = 0.01) and duct loss (P < 0.000) were observed in group 4. Multiple episodes of rejection displayed significant association with central perivenulitis (P = 0.002) and bile duct loss (P < 0.001). Conclusions: Histological analysis in large series of LDLT recipients highlights the spectrum of complications in different time zones. Late acute and chronic rejection occurred as early as 3 months posttransplant. Central perivenulitis and bile duct atrophy were associated with repeated episodes of rejection and deterioration. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0377-4929 |
| Relation: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=802;epage=808;aulast=Rastogi; https://doaj.org/toc/0377-4929 |
| DOI: | 10.4103/ijpm.ijpm_408_21 |
| URL الوصول: | https://doaj.org/article/6ad7d17b9b764b8b939c20c65c58a51f |
| رقم الانضمام: | edsdoj.6ad7d17b9b764b8b939c20c65c58a51f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03774929 |
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| DOI: | 10.4103/ijpm.ijpm_408_21 |