Academic Journal
Plasma p‐tau217 concordance with amyloid PET among ethnically diverse older adults
| العنوان: | Plasma p‐tau217 concordance with amyloid PET among ethnically diverse older adults |
|---|---|
| المؤلفون: | Breton M. Asken, Jesse C. DeSimone, Wei‐En Wang, Karen N. McFarland, Franchesca Arias, Shellie‐Anne Levy, Jacob Fiala, Idaly Velez‐Uribe, Robin P. Mayrand, Luana Okino Sawada, Christian Freytes, Michael Adeyosoye, Warren W. Barker, Elizabeth A. Crocco, Steven T. DeKosky, Malek Adjouadi, Monica Rosselli, Michael Marsiske, Melissa J. Armstrong, Glenn E. Smith, Rosie Curiel Cid, David A. Loewenstein, David E. Vaillancourt, Ranjan Duara |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | Alzheimer's, ALZPath, amyloid PET, biomarkers, dementia, ethnicity, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Abstract INTRODUCTION Commercially available plasma p‐tau217 biomarker tests are not well studied in ethnically diverse samples. METHODS We evaluated associations between ALZPath plasma p‐tau217 and amyloid‐beta positron emission tomography (Aβ‐PET) in Hispanic/Latino (88% of Cuban or South American ancestry) and non‐Hispanic/Latino older adults. One‐ and two‐cutoff ranges were derived and evaluated to assess agreement with Aβ‐PET. RESULTS A total of 239 participants underwent blood draw and Aβ‐PET (age 70.8 ± 7.8, 55.2% female, education 15.6 ± 3.4 years, 48.9% Hispanic/Latino, 94.9% white). Plasma p‐tau217 showed excellent discrimination of Aβ‐PET positive and negative participants (visual read: AUC = 0.91 [0.87–0.95], p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-8729 |
| Relation: | https://doaj.org/toc/2352-8729 |
| DOI: | 10.1002/dad2.12617 |
| URL الوصول: | https://doaj.org/article/6a96aa6ce47742c6a1d4d3c40f5209d4 |
| رقم الانضمام: | edsdoj.6a96aa6ce47742c6a1d4d3c40f5209d4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23528729 |
|---|---|
| DOI: | 10.1002/dad2.12617 |