Academic Journal
Predicting the receptive range of olfactory receptors.
| العنوان: | Predicting the receptive range of olfactory receptors. |
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| المؤلفون: | Rafi Haddad, Liran Carmel, Noam Sobel, David Harel |
| المصدر: | PLoS Computational Biology, Vol 4, Iss 2, p e18 (2008) |
| بيانات النشر: | Public Library of Science (PLoS), 2008. |
| سنة النشر: | 2008 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Although the family of genes encoding for olfactory receptors was identified more than 15 years ago, the difficulty of functionally expressing these receptors in an heterologous system has, with only some exceptions, rendered the receptive range of given olfactory receptors largely unknown. Furthermore, even when successfully expressed, the task of probing such a receptor with thousands of odors/ligands remains daunting. Here we provide proof of concept for a solution to this problem. Using computational methods, we tune an electronic nose to the receptive range of an olfactory receptor. We then use this electronic nose to predict the receptors' response to other odorants. Our method can be used to identify the receptive range of olfactory receptors, and can also be applied to other questions involving receptor-ligand interactions in non-olfactory settings. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1553-734X 1553-7358 |
| Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18248088/pdf/?tool=EBI; https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358 |
| DOI: | 10.1371/journal.pcbi.0040018 |
| URL الوصول: | https://doaj.org/article/6a8d0d7223e144578cdea528b9594d70 |
| رقم الانضمام: | edsdoj.6a8d0d7223e144578cdea528b9594d70 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1553734X 15537358 |
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| DOI: | 10.1371/journal.pcbi.0040018 |