Academic Journal
Effects of different ventilatory settings on alveolar and pulmonary microvessel dimensions in pigs
| العنوان: | Effects of different ventilatory settings on alveolar and pulmonary microvessel dimensions in pigs |
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| المؤلفون: | Elisa Damiani, Erika Casarotta, Caterina Di Bella, Margherita Galosi, Alessio Angorini, Federica Serino, Adolfo Maria Tambella, Fulvio Laus, Samuele Zuccari, Alessio Salvucci Salice, Roberta Domizi, Andrea Carsetti, Can Ince, Abele Donati |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Mechanical ventilation, Pulmonary microcirculation, Ventilation/perfusion matching, Incident dark field, Hand-held vital microscopy, Medicine, Science |
| الوصف: | Abstract Mechanical ventilation with high tidal volume (TV) or positive end-expiratory pressure (PEEP) may induce lung overinflation and increased pulmonary vascular resistance to flow. In 8 healthy mechanically ventilated pigs, we evaluated whether incident dark field (IDF) vital microscopy, applied through a small thoracotomy, could be used to evaluate changes in alveolar and pulmonary microvessel dimensions under different ventilator settings. High TV (12 ml/kg) increased alveolar diameters (from 99 ± 13 to 114 ± 6 μm, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-82244-7 |
| URL الوصول: | https://doaj.org/article/6a1ec6823864437a83407af62a5c173e |
| رقم الانضمام: | edsdoj.6a1ec6823864437a83407af62a5c173e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-82244-7 |