Academic Journal
#242 : Correlation of Sperm DNA Fragmentation with Laboratory Performance in Good and Poor Prognosis Patient Groups at Morula IVF Jakarta
| العنوان: | #242 : Correlation of Sperm DNA Fragmentation with Laboratory Performance in Good and Poor Prognosis Patient Groups at Morula IVF Jakarta |
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| المؤلفون: | Nurul Hikmawati, Pitra Rahmawati, Arief Boediono, Ivan Rizal Sini |
| المصدر: | Fertility & Reproduction, Vol 05, Iss 04, Pp 426-426 (2023) |
| بيانات النشر: | World Scientific Publishing, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Reproduction |
| مصطلحات موضوعية: | Reproduction, QH471-489 |
| الوصف: | BACKGROUND AND AIMS: Infertility in males contributes to about 40% of cases of infertility in couples, either as the main factor or along with female factors. Fragmentation of sperm DNA is known as a cause of male infertility, which impacts the failure of couples to undergo assisted reproductive programs, such as embryo development and recurrent miscarriage. However, some literature studies are still debating this. This research aims to determine the correlation between sperm DNA fragmentation and IVF laboratory performance. METHODS: Infertile couples undergoing an in vitro fertilization program at Morula IVF Jakarta in 2022 are the samples for this study. We divided them into two groups: good prognosis (maternal age [Formula: see text]38 years, AFC[Formula: see text]7; AMH[Formula: see text]1.1) and poor prognosis (maternal age > 38 years, AFC 14.9% had a significant negative correlation with IVF laboratory performance, particularly in the fifth-day embryo quality and blastocyst rate in the good prognosis group. Whereas in the group with poor prognosis, all laboratory performance parameters were not affected by high sperm DNA fragmentation values. CONCLUSIONS: Sperm DNA fragmentation rate > 14.9% correlated with fifth-day embryo quality and a lower blastocyst rate in the good prognosis group. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 26613182 2661-3174 2661-3182 |
| Relation: | https://doaj.org/toc/2661-3182; https://doaj.org/toc/2661-3174 |
| DOI: | 10.1142/S2661318223742108 |
| URL الوصول: | https://doaj.org/article/6a1afdeb8d354a7a8253c355835f12e2 |
| رقم الانضمام: | edsdoj.6a1afdeb8d354a7a8253c355835f12e2 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 26613182 26613174 |
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| DOI: | 10.1142/S2661318223742108 |