التفاصيل البيبلوغرافية
| العنوان: |
Acute low frequency dorsal subthalamic nucleus stimulation improves verbal fluency in Parkinson's disease |
| المؤلفون: |
Darrin J. Lee, Neil M. Drummond, Utpal Saha, Philippe De Vloo, Robert F. Dallapiazza, Robert Gramer, Tameem M. Al-Ozzi, Jordan Lam, Aaron Loh, Gavin J.B. Elias, Alexandre Boutet, Jurgen Germann, Mojgan Hodaie, Alfonso Fasano, Renato P. Munhoz, William Hutchison, Melanie Cohn, Robert Chen, Suneil K. Kalia, Andres M. Lozano |
| المصدر: |
Brain Stimulation, Vol 14, Iss 4, Pp 754-760 (2021) |
| بيانات النشر: |
Elsevier, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
Parkinson's disease, Treatment, Deep brain stimulation, Subthalamic nucleus, Verbal fluency, Theta, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Background: Parkinson's disease (PD) is a common neurodegenerative disorder that results in movement-related dysfunction and has variable cognitive impairment. Deep brain stimulation (DBS) of the dorsal subthalamic nucleus (STN) has been shown to be effective in improving motor symptoms; however, cognitive impairment is often unchanged, and in some cases, worsened particularly on tasks of verbal fluency. Traditional DBS strategies use high frequency gamma stimulation for motor symptoms (∼130 Hz), but there is evidence that low frequency theta oscillations (5–12 Hz) are important in cognition. Methods: We tested the effects of stimulation frequency and location on verbal fluency among patients who underwent STN DBS implantation with externalized leads. During baseline cognitive testing, STN field potentials were recorded and the individual patients’ peak theta frequency power was identified during each cognitive task. Patients repeated cognitive testing at five different stimulation settings: no stimulation, dorsal contact gamma (130 Hz), ventral contact gamma, dorsal theta (peak baseline theta) and ventral theta (peak baseline theta) frequency stimulation. Results: Acute left dorsal peak theta frequency STN stimulation improves overall verbal fluency compared to no stimulation and to either dorsal or ventral gamma stimulation. Stratifying by type of verbal fluency probes, verbal fluency in episodic categories was improved with dorsal theta stimulation compared to all other conditions, while there were no differences between stimulation conditions in non-episodic probe conditions. Conclusion: Here, we provide evidence that dorsal STN theta stimulation may improve verbal fluency, suggesting a potential possibility of integrating theta stimulation into current DBS paradigms to improve cognitive outcomes. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1935-861X |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1935861X21000863; https://doaj.org/toc/1935-861X |
| DOI: |
10.1016/j.brs.2021.04.016 |
| URL الوصول: |
https://doaj.org/article/69051f8957544f8281dc51172999f69e |
| رقم الانضمام: |
edsdoj.69051f8957544f8281dc51172999f69e |
| قاعدة البيانات: |
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