التفاصيل البيبلوغرافية
| العنوان: |
Genome-wide association study of stimulant dependence |
| المؤلفون: |
Jiayi Cox, Richard Sherva, Leah Wetherill, Tatiana Foroud, Howard J. Edenberg, Henry R. Kranzler, Joel Gelernter, Lindsay A. Farrer |
| المصدر: |
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021) |
| بيانات النشر: |
Nature Publishing Group, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Abstract Stimulant dependence is heritable, but specific genetic factors underlying the trait have not been identified. A genome-wide association study for stimulant dependence was performed in a discovery cohort of African- (AA) and European-ancestry (EA) subjects ascertained for genetic studies of alcohol, opioid, and cocaine use disorders. The sample comprised individuals with DSM-IV stimulant dependence (393 EA cases, 5288 EA controls; 155 AA cases, 5603 AA controls). An independent cohort from the family-based Collaborative Study on the Genetics of Alcoholism (532 EA cases, 7635 EA controls; 53 AA cases, AA 3352 controls) was used for replication. One variant in SLC25A16 (rs2394476, p = 3.42 × 10−10, odds ratio [OR] = 3.70) was GWS in AAs. Four other loci showed suggestive evidence, including KCNA4 in AAs (rs11500237, p = 2.99 × 10−7, OR = 2.31) which encodes one of the potassium voltage-gated channel protein that has been linked to several other substance use disorders, and CPVL in the combined population groups (rs1176440, p = 3.05 × 10−7, OR = 1.35), whose expression was previously shown to be upregulated in the prefrontal cortex from users of cocaine, cannabis, and phencyclidine. Analysis of the top GWAS signals revealed a significant enrichment with nicotinic acetylcholine receptor genes (adjusted p = 0.04) and significant pleiotropy between stimulant dependence and alcohol dependence in EAs (p adj = 3.6 × 10−3), an anxiety disorder in EAs (p adj = 2.1 × 10−4), and ADHD in both AAs (p adj = 3.0 × 10−33) and EAs (p adj = 6.7 × 10−35). Our results implicate novel genes and pathways as having roles in the etiology of stimulant dependence. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2158-3188 |
| Relation: |
https://doaj.org/toc/2158-3188 |
| DOI: |
10.1038/s41398-021-01440-5 |
| URL الوصول: |
https://doaj.org/article/68ea6f00cf104255b0cf977f08fbb4cf |
| رقم الانضمام: |
edsdoj.68ea6f00cf104255b0cf977f08fbb4cf |
| قاعدة البيانات: |
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