التفاصيل البيبلوغرافية
| العنوان: |
Crescentic poststreptococcal acute glomerulonephritis accompanied by small vessel vasculitis: case report of an elderly male |
| المؤلفون: |
Keiko Yano, Hiroyuki Suzuki, Takashi Oda, Yoshihiko Ueda, Tatsuo Tsukamoto, Eri Muso |
| المصدر: |
BMC Nephrology, Vol 20, Iss 1, Pp 1-6 (2019) |
| بيانات النشر: |
BMC, 2019. |
| سنة النشر: |
2019 |
| المجموعة: |
LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: |
Poststreptococcal acute glomerulonephritis, Anti-neutrophil cytoplasmic antibody-associated vasculitis, Peritubular capillaritis, Hilar arteriolitis, Nephritis-associated plasmin receptor, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: |
Abstract Background Poststreptococcal acute glomerulonephritis (PSAGN) in the elderly tends to have a severe clinical course and often presents with crescentic necrotizing glomerulonephritis in the renal biopsy. However, vasculitis lesions are unusual. Case presentation We present a 71-year-old man who was admitted to our hospital for a recurrent gout attack with a rapid decline of renal function. Low C3 levels and a high anti-streptolysin O titer were observed, while myeloperoxidase- and proteinase 3- antineutrophil cytoplasmic antibody (ANCA) were negative. In addition to cellular crescent and necrosis lesions, diffuse peritubular capillaritis and venulitis as well as small arteriole vasculitis in the glomerular hilus were also apparent. Although granular C3c deposits in the capillary wall and hump lesions were not found, immunofluorescent staining for nephritis-associated plasmin receptor (NAPlr) and in situ zymography for plasmin activity were both positive. We thus diagnosed PSAGN accompanied by small vessel vasculitis. Steroid therapy gradually improved the patient’s renal function, and hemodialysis was discontinued after 1 month. Conclusions In our case, streptococcus infection might have concurrently provoked vasculitis, and NAPlr staining was useful for confirming diagnosis. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2369 |
| Relation: |
https://doaj.org/toc/1471-2369 |
| DOI: |
10.1186/s12882-019-1663-9 |
| URL الوصول: |
https://doaj.org/article/a68c026a23544218a8235872298c9afa |
| رقم الانضمام: |
edsdoj.68c026a23544218a8235872298c9afa |
| قاعدة البيانات: |
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