التفاصيل البيبلوغرافية
| العنوان: |
Enhancing bone tissue engineering with nanocomposites based on NiO nanoparticles/graphene oxide |
| المؤلفون: |
Ke Zhang, Mingyang Jiang, Shenyi Lu, Huaan Zhao, Donghao Li, Ruilan Ma, Lin Li |
| المصدر: |
Alexandria Engineering Journal, Vol 109, Iss , Pp 431-442 (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Engineering (General). Civil engineering (General) |
| مصطلحات موضوعية: |
Bone tissue engineering, Graphene oxide, Mechanical properties, Nanocrystalline Hydroxyapatite, Nickel oxide nanoparticles, Poly (L-lactic acid)-based nanocomposites, Engineering (General). Civil engineering (General), TA1-2040 |
| الوصف: |
Through the creation and characterization of novel poly (L-lactic acid) (PLLA)-based nanocomposites containing graphene oxide (GO), nanocrystalline hydroxyapatite (nano-HAP), and nickel oxide (NiO) nanoparticles, this study seeks to improve the performance of bone tissue scaffolds. Utilizing a casting procedure to create nanocomposites, wet chemical methods were used to synthesize nano-HAP. X-ray diffraction, transmission electron microscopy, and Fourier transform infrared spectroscopy were used to characterize the materials. The nanocomposite comprising 5 % GO + 5 % NiO + 10 % nano-HAP showed a 110 % increase in tensile modulus, a 38 % increase in extension, and a 29 % increase in load-bearing capacity compared to plain PLLA. The results showed a considerable increase in mechanical strength. On the surfaces of the nanocomposite, osteoblast adhesion and proliferation increased by 185 %, according to biological tests. Studies on degradation revealed regulated rates that matched bones' natural mending process while preserving a pH environment that was steady. According to these results, adding nanostructures to PLLA scaffolds improves their mechanical and biological properties considerably, which may lead to therapeutic uses in bone tissue engineering in the future. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1110-0168 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1110016824009815; https://doaj.org/toc/1110-0168 |
| DOI: |
10.1016/j.aej.2024.08.085 |
| URL الوصول: |
https://doaj.org/article/688d86573c954f239fc04b3b915c8b66 |
| رقم الانضمام: |
edsdoj.688d86573c954f239fc04b3b915c8b66 |
| قاعدة البيانات: |
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