Academic Journal
Evaluating the Effectiveness of Adding Magnesium Chloride to Conventional Protocol of Citrate Alkali Therapy in Children with Urolithiasis
| العنوان: | Evaluating the Effectiveness of Adding Magnesium Chloride to Conventional Protocol of Citrate Alkali Therapy in Children with Urolithiasis |
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| المؤلفون: | Alaleh Gheissari, Amin Ziaee, Faezeh Farhang, Fatemeh Farhang, Zahra Talaei, Alireza Merrikhi, Taghi Ghafghazi, Mohsen Moslehi |
| المصدر: | International Journal of Preventive Medicine, Vol 3, Iss 11, Pp 791-797 (2012) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2012. |
| سنة النشر: | 2012 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Children, magnesium chloride, nephrolithiasis, potassium citrate, urinary parameters, Medicine |
| الوصف: | Background: Potassium citrate (K-Cit) is one of the medications widely used in patients with urolithiasis. However, in some cases with calcium oxalate (CaOx) urolithiasis, the significant response to alkaline therapy with K-Cit alone does not occur. There is scarce published data on the effect of magnesium chloride (Mg-Cl 2 ) on urolithiasis in pediatric patients. This study aimed to evaluate the effect of a combination of K-Cit - MgCl 2 as oral supplements on urinary parameters in children with CaOx urolithiasis. Methods: This study was conducted on 24 children with CaOx urolithiasis supplements included potassium citrate (K-Cit) and magnesium chloride (Mg-Cl 2 ). The serum and urinary electrolytes were measured before (phase 0) and after prescribing K-Cit alone (phase 1) and a combination of K-Cit and Mg-Cl 2 (phase 2). Each phase of therapy lasted for 4 weeks. Results: The mean age of patients was 6.46 ± 2.7 years. Hyperoxaluria and hypercalciuria were seen in 66% and 41% of patients, respectively. Serum magnesium increased significantly during phase 2 comparing with phase 0. Urinary citrate level was significantly higher in phase 1 and 2 in comparison with phase 0, P < 0.05. In addition, urinary oxalate excretion was significantly diminished in phase 2 comparing with phase 0 and 1, P < 0.05. Soft stool was reported by 4 patients, but not severe enough to discontinue medications. Conclusions: These results suggested that a combination of K-Cit and Mg-Cl 2 chloride is more effective on decreasing urinary oxalate excretion than K-Cit alone. The Iranian Clinical Trial registration number IRCT138707091282N1. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-7802 2008-8213 |
| Relation: | http://www.ijpvmjournal.net/article.asp?issn=2008-7802;year=2012;volume=3;issue=11;spage=791;epage=797;aulast=Gheissari; https://doaj.org/toc/2008-7802; https://doaj.org/toc/2008-8213 |
| URL الوصول: | https://doaj.org/article/68780bff9d2e40adb3c2752dd699e471 |
| رقم الانضمام: | edsdoj.68780bff9d2e40adb3c2752dd699e471 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20087802 20088213 |
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