التفاصيل البيبلوغرافية
| العنوان: |
Integrative neurovascular coupling and neurotransmitter analyses in anisometropic and visual deprivation amblyopia children |
| المؤلفون: |
Xiaopan Zhang, Liang Liu, Yadong Li, Xiao Li, Kejia Wang, Shaoqiang Han, Mengzhu Wang, Yong Zhang, Guangying Zheng, Jingliang Cheng, Baohong Wen |
| المصدر: |
iScience, Vol 27, Iss 6, Pp 109988- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
health sciences, clinical neuroscience, bioinformatics, Science |
| الوصف: |
Summary: The association between visual abnormalities and impairments in cerebral blood flow and brain region potentially results in neural dysfunction of amblyopia. Nevertheless, the differences in the complex mechanisms of brain neural network coupling and its relationship with neurotransmitters remain unclear. Here, the neurovascular coupling mechanism and neurotransmitter activity in children with anisometropic amblyopia (AA) and visual deprivation amblyopia (VDA) was explored. The neurovascular coupling of 17 brain regions in amblyopia children was significantly abnormal than in normal controls. The classification abilities of coupling units in brain regions differed between two types of amblyopia. Correlations between different coupling effects and neurotransmitters were different. The findings of this study demonstrate a correlation between the neurovascular coupling and neurotransmitter in children with AA and VDA, implying their impaired neurovascular coupling function and potential molecular underpinnings. The neuroimaging evidence revealed herein offers potential for the development of neural therapies for amblyopia. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004224012136; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2024.109988 |
| URL الوصول: |
https://doaj.org/article/685828d440424e53aae87c2ac2e8cba7 |
| رقم الانضمام: |
edsdoj.685828d440424e53aae87c2ac2e8cba7 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder