التفاصيل البيبلوغرافية
| العنوان: |
Immunomodulatory effects of fucoidan extracted from Sargassum fusiforme in RAW 264.7 macrophages |
| المؤلفون: |
Serim Park, Yunjin Choi, Seonmi Ji, Seonghui Kim, Seon Yeong Ji, Yung Hyun Choi, You-Jin Jeon, Bomi Ryu, Jun-Geon Je, Suengmok Cho |
| المصدر: |
Fisheries and Aquatic Sciences, Vol 27, Iss 12, Pp 855-865 (2024) |
| بيانات النشر: |
The Korean Society of Fisheries and Aquatic Science, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Aquaculture. Fisheries. Angling |
| مصطلحات موضوعية: |
Brown seaweed, Fucoidan, Immune modulation, Sargassum fusiforme, Signaling pathway, Aquaculture. Fisheries. Angling, SH1-691 |
| الوصف: |
Sargassum fusiforme, a brown alga, has been traditionally used as an herbal remedy. While previous studies have reported its immunomodulatory properties, the specific immune-modulating effects of fucoidan extracted from S. fusiforme remain underexplored. This study aimed to assess the immune-enhancing properties of S. fusiforme fucoidan (SFF) using the RAW 264.7 macrophage model. SFF significantly increased nitric oxide (NO) production and phagocytic activity at 25–100 μg/mL concentrations, without exhibiting cytotoxicity. RAW 264.7 macrophages treated with SFF adopted a spindle shape with elongated pseudopodia, indicating an activated state. Additionally, SFF upregulated the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), while promoting the secretion of cytokines such as tumor necrosis factor-α, interleukin (IL)-6, and IL-1β in a dose-dependent manner. SFF also promoted the activation of nuclear factor kappa B and mitogen-activated protein kinase signaling pathways. These findings suggest that SFF exhibits potent immunomodulatory activity in the RAW 264.7 macrophage model and holds potential as a functional food to support immune health. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2234-1757 |
| Relation: |
http://www.e-fas.org/archive/view_article?doi=10.47853/FAS.2024.e77; https://doaj.org/toc/2234-1757 |
| DOI: |
10.47853/FAS.2024.e77 |
| URL الوصول: |
https://doaj.org/article/68528297523744d3bef4e40f23ad76ea |
| رقم الانضمام: |
edsdoj.68528297523744d3bef4e40f23ad76ea |
| قاعدة البيانات: |
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