التفاصيل البيبلوغرافية
| العنوان: |
Caspase-1 variant influencing CSF tau and FDG PET levels in non-demented elders from the ADNI cohort |
| المؤلفون: |
Yi Liu, Meng-Shan Tan, Zuo-Teng Wang, Wei Xu, Lan Tan |
| المصدر: |
BMC Neurology, Vol 22, Iss 1, Pp 1-7 (2022) |
| بيانات النشر: |
BMC, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Neurology. Diseases of the nervous system |
| مصطلحات موضوعية: |
Caspase-1, Variant, CSF, Tau pathology, FDG PET, Neurodegeneration, Neurology. Diseases of the nervous system, RC346-429 |
| الوصف: |
Abstract Background Genetic variations in the inflammatory Caspase-1 gene have been shown associated with cognitive function in elderly individuals and in predisposition to Alzheimer’s disease (AD), but its detailed mechanism before the typical AD onset was still unclear. Our current study evaluated the impact of Caspase-1 common variant rs554344 on the pathological processes of brain amyloidosis, tauopathy, and neurodegeneration. Methods Data used in our study were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. We examined the relationship between Caspase-1 rs554344 allele carrier status with AD-related cerebrospinal fluid (CSF), PET, and MRI measures at baseline by using a multiple linear regression model. We also analyzed the longitudinal effects of this variant on the change rates of CSF biomarkers and imaging data using a mixed effect model. Results We found that Caspase-1 variant was significantly associated with FDG PET levels and CSF t-tau levels at baseline in total non-demented elderly group, and especially in mild cognitive impairment (MCI) subgroup. In addition, this variant was also detected associated with CSF p-tau levels in MCI subgroup. The mediation analysis showed that CSF p-tau partially mediated the association between Caspase-1 variant and CSF t-tau levels, accounting for 80% of the total effect. Conclusions Our study indicated a potential role of Caspase-1 variant in influencing cognitive function might through changing tau related-neurodegeneration process. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2377 |
| Relation: |
https://doaj.org/toc/1471-2377 |
| DOI: |
10.1186/s12883-022-02582-9 |
| URL الوصول: |
https://doaj.org/article/67981abe512344bbbb9eaef5823ed6a2 |
| رقم الانضمام: |
edsdoj.67981abe512344bbbb9eaef5823ed6a2 |
| قاعدة البيانات: |
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