Academic Journal
Evaluation of the Reparative Effect of Sinomenine in an Acetaminophen-Induced Liver Injury Model
| العنوان: | Evaluation of the Reparative Effect of Sinomenine in an Acetaminophen-Induced Liver Injury Model |
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| المؤلفون: | Ahmet Kayalı, Ejder Saylav Bora, Hüseyin Acar, Oytun Erbaş |
| المصدر: | Current Issues in Molecular Biology, Vol 46, Iss 1, Pp 923-933 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | drug-induced hepatotoxicity, Acetaminophen, Sinomenine, BMP-7, Biology (General), QH301-705.5 |
| الوصف: | Due to its rising global prevalence, liver failure treatments are urgently needed. Sinomenine (SIN), an alkaloid from sinomenium acutum, is being studied for its liver-repair properties due to Acetaminophen (APAP) overdose. SIN’s effect on APAP-induced hepatotoxicity in rats was examined histologically and biochemically. Three groups of 30 adult male Wistar rats were created: control, APAP-only, and APAP + SIN. Histopathological and biochemical analyses were performed on liver samples after euthanasia. SIN is significantly protected against APAP damage. Compared to APAP-only, SIN reduced cellular injury and preserved hepatocellular architecture. The APAP + SIN Group had significantly lower ALT, MDA, and GSH levels, protecting against hepatocellular damage and oxidative stress. SIN also had dose-dependent antioxidant properties. When examining critical regulatory proteins, SIN partially restored Sirtuin 1 (SIRT1) levels. While BMP-7 levels were unaffected, histopathological evidence and hepatocyte damage percentages supported SIN’s liver-restorative effect. SIN protected and repaired rats’ livers from APAP-induced liver injury. This study suggests that SIN may treat acute liver damage, warranting further research into its long-term effects, optimal dosage, and clinical applications. These findings aid liver-related emergency department interventions and life-saving treatments. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1467-3045 1467-3037 |
| Relation: | https://www.mdpi.com/1467-3045/46/1/59; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045 |
| DOI: | 10.3390/cimb46010059 |
| URL الوصول: | https://doaj.org/article/6752f1efca9a44418aad479a0ef9fa46 |
| رقم الانضمام: | edsdoj.6752f1efca9a44418aad479a0ef9fa46 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14673045 14673037 |
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| DOI: | 10.3390/cimb46010059 |