Academic Journal
The exosome journey: from biogenesis to uptake and intracellular signalling
| العنوان: | The exosome journey: from biogenesis to uptake and intracellular signalling |
|---|---|
| المؤلفون: | Sonam Gurung, Dany Perocheau, Loukia Touramanidou, Julien Baruteau |
| المصدر: | Cell Communication and Signaling, Vol 19, Iss 1, Pp 1-19 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Cytology |
| مصطلحات موضوعية: | Exosomes, Extracellular vesicles, Intercellular communication, Targeting, Multivesicular bodies, Tetraspanins, Medicine, Cytology, QH573-671 |
| الوصف: | Abstract The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials testing exosomes for diagnostic and therapeutic applications are generating remarkable interest from the scientific community and investors. Exosomes are small extracellular vesicles secreted by all cell types playing intercellular communication roles in health and disease by transferring cellular cargoes such as functional proteins, metabolites and nucleic acids to recipient cells. An in-depth understanding of exosome biology is therefore essential to ensure clinical development of exosome based investigational therapeutic products. Here we summarise the most up-to-date knowkedge about the complex biological journey of exosomes from biogenesis and secretion, transport and uptake to their intracellular signalling. We delineate the major pathways and molecular players that influence each step of exosome physiology, highlighting the routes of interest, which will be of benefit to exosome manipulation and engineering. We highlight the main controversies in the field of exosome research: their adequate definition, characterisation and biogenesis at plasma membrane. We also delineate the most common identified pitfalls affecting exosome research and development. Unravelling exosome physiology is key to their ultimate progression towards clinical applications. Video Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1478-811X |
| Relation: | https://doaj.org/toc/1478-811X |
| DOI: | 10.1186/s12964-021-00730-1 |
| URL الوصول: | https://doaj.org/article/67312e10ddd846b5983bbf8e4658272d |
| رقم الانضمام: | edsdoj.67312e10ddd846b5983bbf8e4658272d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1478811X |
|---|---|
| DOI: | 10.1186/s12964-021-00730-1 |