Academic Journal
Comparison of a combination test (1 μg ACTH test plus glucagon test) versus 1 μg ACTH test and glucagon test in the evaluation of the hypothalamic-pituitary-adrenal axis in patients with pituitary disorders
| العنوان: | Comparison of a combination test (1 μg ACTH test plus glucagon test) versus 1 μg ACTH test and glucagon test in the evaluation of the hypothalamic-pituitary-adrenal axis in patients with pituitary disorders |
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| المؤلفون: | Kursad Unluhizarci, Emel Oguz Kokoglu, Ayşa Hacioglu, Zuleyha Karaca, Fahrettin Kelestimur |
| المصدر: | Archives of Endocrinology and Metabolism, Vol 64, Iss 5, Pp 608-613 (2020) |
| بيانات النشر: | Brazilian Society of Endocrinology and Metabolism, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | Low-dose ACTH test, glucagon test, pituitary, adrenal insufficiency, Medicine, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | ABSTRACT Objective To investigate whether a combination of the low-dose (1 µg) adrenocorticotropin (ACTH) stimulation test and glucagon stimulation test (GST) could overcome the problem of equivocal results with the GST or ACTH test alone in patients with pituitary disorders. Subjects and methods The study included 41 adult patients with pituitary disorders and 20 healthy subjects who underwent evaluation of cortisol response to ACTH, GST, and a combination of both tests. Blood samples for cortisol measurement were obtained at baseline and 30, 60, 90, and 120 minutes after intravenous administration of ACTH 1 μg and 90, 120, 150, 180, 210, and 240 minutes after subcutaneous injection of glucagon 1 mg. The combination test was performed by injecting ACTH 1 µg at the 180-minute time point of the GST, with blood samples for cortisol measurement obtained at 210 and 240 minutes. Results Overall, 28 patients with normal cortisol response to both tests also had a normal cortisol response to the combination test. Ten patients with adrenal insufficiency in both tests also had adrenal insufficiency in the combination test, including a patient who had a peak cortisol value of 12.4 µg/dL (which is the cutoff value for the combination test). Two patients with adrenal insufficiency in the ACTH stimulation test and one patient with adrenal insufficiency in the GST had normal cortisol responses to the combination test. Conclusion By using an appropriate cutoff value, the combination test may offer additional information in patients with equivocal results in the GST and ACTH stimulation test. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2359-4292 2359-3997 |
| Relation: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972020000500608&tlng=en; https://doaj.org/toc/2359-4292 |
| DOI: | 10.20945/2359-3997000000266 |
| URL الوصول: | https://doaj.org/article/66c09130f85146d5b50d43d6950d9714 |
| رقم الانضمام: | edsdoj.66c09130f85146d5b50d43d6950d9714 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23594292 23593997 |
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| DOI: | 10.20945/2359-3997000000266 |