التفاصيل البيبلوغرافية
| العنوان: |
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson’s disease |
| المؤلفون: |
Marthe H. R. Ludtmann, Plamena R. Angelova, Mathew H. Horrocks, Minee L. Choi, Margarida Rodrigues, Artyom Y. Baev, Alexey V. Berezhnov, Zhi Yao, Daniel Little, Blerida Banushi, Afnan Saleh Al-Menhali, Rohan T. Ranasinghe, Daniel R. Whiten, Ratsuda Yapom, Karamjit Singh Dolt, Michael J. Devine, Paul Gissen, Tilo Kunath, Morana Jaganjac, Evgeny V. Pavlov, David Klenerman, Andrey Y. Abramov, Sonia Gandhi |
| المصدر: |
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| بيانات النشر: |
Nature Portfolio, 2018. |
| سنة النشر: |
2018 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parkinson’s disease. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-018-04422-2 |
| URL الوصول: |
https://doaj.org/article/66a1b1816bc747869ab5c60b308732ab |
| رقم الانضمام: |
edsdoj.66a1b1816bc747869ab5c60b308732ab |
| قاعدة البيانات: |
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