التفاصيل البيبلوغرافية
| العنوان: |
Oncolytic adenovirus MEM-288 encoding membrane-stable CD40L and IFNβ induces an anti-tumor immune response in high grade serous ovarian cancer |
| المؤلفون: |
Pamela N. Peters, Regina S. Whitaker, Felicia Lim, Shonagh Russell, Elizabeth A. Bloom, Justin Pollara, Kyle C. Strickland, Mark J. Cantwell, Amer Beg, Andrew Berchuck, Scott Antonia, Rebecca A. Previs |
| المصدر: |
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101056- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
Immunotherapy, Ovarian cancer, Oncolytic virus, Ascites, ELISPOT, ELISA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Single agent immune checkpoint inhibitors have been ineffective for patients with advanced stage and recurrent high grade serous ovarian cancer (HGSOC). Using pre-clinical models of HGSOC, we evaluated the anti-tumor and immune stimulatory effects of an oncolytic adenovirus, MEM-288. This conditionally replicative virus encodes a modified membrane stable CD40L and IFNβ. We demonstrated this virus successfully infects HGSOC cell lines and primary human ascites samples in vitro. We evaluated the anti-tumor and immunostimulatory activity in vivo in immune competent mouse models. Intraperitoneal delivery of MEM-288 decreased ascites and solid tumor burden compared to controls, and treatment generated a systemic anti-tumor immune response. The tumor microenvironment had a higher proportion of anti-tumor macrophages and decreased markers of angiogenesis. MEM-288 is a promising immunotherapy agent in HGSOC, with further pre-clinical studies required to understand the mechanism of action in the peritoneal microenvironment and clinical activity in combination with other therapies. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1476-5586 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S1476558624000976; https://doaj.org/toc/1476-5586 |
| DOI: |
10.1016/j.neo.2024.101056 |
| URL الوصول: |
https://doaj.org/article/6671225534084b968c89f7e95e76d5ae |
| رقم الانضمام: |
edsdoj.6671225534084b968c89f7e95e76d5ae |
| قاعدة البيانات: |
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