Academic Journal
SARS-CoV-2 vaccine-triggered autoimmunity: Molecular mimicry and/or bystander activation of the immune system
| العنوان: | SARS-CoV-2 vaccine-triggered autoimmunity: Molecular mimicry and/or bystander activation of the immune system |
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| المؤلفون: | Azam Safary, Mostafa Akbarzadeh-Khiavi, Jaleh Barar, Yadollah Omidi |
| المصدر: | BioImpacts, Vol 13, Iss 4, Pp 269-273 (2023) |
| بيانات النشر: | Tabriz University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | autoimmunity, bystander activation, covid-19 vaccine, molecular mimicry, post-vaccination, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Induced autoimmunity or autoinflammatory-like conditions as a rare vaccine-related adverse event have been reported following COVID-19 vaccination. Such inadvertent adverse reactions have raised somewhat concerns about the long-term safety of the developed vaccines. Such multifactorial phenomena may be related to the cross-reactivity between the viral-specific antigens with the host self-proteins through molecular mimicry mechanism and/or nonspecific bystander activation of the non-target antigen-independent immunity by the entities of the vaccine products. However, due to the low incidence of the reported/identified individuals and insufficient evidence, autoimmunity following the COVID-19 vaccination has not been approved. Thereby, it seems that further designated studies might warrant post-monitoring of the inevitable adverse immunologic reactions in the vaccinated individuals, especially among hypersensitive cases, to address possible immunological mechanisms induced by the viral vaccines, incorporated adjuvants, and even vaccine delivery systems. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2228-5660 2228-5652 |
| Relation: | https://bi.tbzmed.ac.ir/PDF/bi-13-269.pdf; https://doaj.org/toc/2228-5660; https://doaj.org/toc/2228-5652 |
| DOI: | 10.34172/bi.2023.27494 |
| URL الوصول: | https://doaj.org/article/664d713f2795424db39d74204bc65b4b |
| رقم الانضمام: | edsdoj.664d713f2795424db39d74204bc65b4b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22285660 22285652 |
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| DOI: | 10.34172/bi.2023.27494 |