التفاصيل البيبلوغرافية
| العنوان: |
Equilibria in Aqueous Cobalt(II)—Reduced Schiff Base N-(2-hydroxybenzyl)alanine System: Chemical Characterization, Kinetic Analysis, Antimicrobial and Cytotoxic Properties |
| المؤلفون: |
Magdalena Woźniczka, Manas Sutradhar, Armando J. L. Pombeiro, Mirosława Świątek, Marek Pająk, Joanna Gądek-Sobczyńska, Magdalena Chmiela, Weronika Gonciarz, Beata Pasternak, Aleksander Kufelnicki |
| المصدر: |
Molecules, Vol 25, Iss 15, p 3462 (2020) |
| بيانات النشر: |
MDPI AG, 2020. |
| سنة النشر: |
2020 |
| المجموعة: |
LCC:Organic chemistry |
| مصطلحات موضوعية: |
cobalt(II) complexes, coordination modes, reduced Schiff base, stability constant, biological activity, UV-Vis spectroscopy, Organic chemistry, QD241-441 |
| الوصف: |
The present study describes the coordination properties of a reduced Schiff base, N-(2-hydroxybenzyl)alanine, towards cobalt(II) using potentiometric as well as spectroscopic (UV-Vis and ESI-MS) methods. The results indicate the formation of six mononuclear complexes showing high stability in aqueous solution. Coordination occurs in the {O−phenolic,N,O−carboxyl} and {N,O−carboxyl} chelation modes, depending on the degree of ligand deprotonation. Examination of the complexation equilibria at pH ca 7, which is important from a biological point of view, allowed to identify two species: [CoL] and [CoL2H]−. The kinetic analysis showed a structural change of those cobalt(II) complexes from octahedral to tetrahedral in accordance with a first-order time relationship. The antimicrobial properties of N-(2-hydroxybenzyl)alanine, cobalt(II) nitrate and of the Co(II) – ligand complexes were determined against Gram-positive bacteria (Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis), Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli, Helicobacter pylori) and a fungal strain (Candida). The results indicate that the complexes are more active for more strains than the ligand alone. Nevertheless, the complexes induce a higher decrease in the metabolic activity of cells but without damage to nuclei. Tetrahedral structures show stronger anti-cellular toxicity than octahedral complexes, which is most likely due to the higher accessibility of the cobalt(II) center. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/25/15/3462; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules25153462 |
| URL الوصول: |
https://doaj.org/article/660f6412a4a449808fe2c9e101f104fa |
| رقم الانضمام: |
edsdoj.660f6412a4a449808fe2c9e101f104fa |
| قاعدة البيانات: |
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