التفاصيل البيبلوغرافية
| العنوان: |
Comparison of miRNA transcriptome of exosomes in three categories of somatic cells with derived iPSCs |
| المؤلفون: |
Chunlai Yu, Mei Zhang, Yucui Xiong, Qizheng Wang, Yuanhua Wang, Shaoling Wu, Sajjad Hussain, Yan Wang, Zhizhong Zhang, Nini Rao, Sheng Zhang, Xiao Zhang |
| المصدر: |
Scientific Data, Vol 10, Iss 1, Pp 1-12 (2023) |
| بيانات النشر: |
Nature Portfolio, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
Abstract Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) through epigenetic manipulation. While the essential role of miRNA in reprogramming and maintaining pluripotency is well studied, little is known about the functions of miRNA from exosomes in this context. To fill this research gap,we comprehensively obtained the 17 sets of cellular mRNA transcriptomic data with 3.93 × 1010 bp raw reads and 18 sets of exosomal miRNA transcriptomic data with 2.83 × 107 bp raw reads from three categories of human somatic cells: peripheral blood mononuclear cells (PBMCs), skin fibroblasts(SFs) and urine cells (UCs), along with their derived iPSCs. Additionally, differentially expressed molecules of each category were identified and used to perform gene set enrichment analysis. Our study provides sets of comparative transcriptomic data of cellular mRNA and exosomal miRNA from three categories of human tissue with three individual biological controls in studies of iPSCs generation, which will contribute to a better understanding of donor cell variation in functional epigenetic regulation and differentiation bias in iPSCs. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2052-4463 |
| Relation: |
https://doaj.org/toc/2052-4463 |
| DOI: |
10.1038/s41597-023-02493-5 |
| URL الوصول: |
https://doaj.org/article/d652f440af4c4ea6aae136e4d4af1eb6 |
| رقم الانضمام: |
edsdoj.652f440af4c4ea6aae136e4d4af1eb6 |
| قاعدة البيانات: |
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