Academic Journal
Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia
| العنوان: | Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia |
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| المؤلفون: | Barbara Glanemann, Karen Humm, Mariana Abreu, Sophie Aspinall, David Buckeridge, Hope Carveth, Hannah Darcy, Jessica Florey, Polly Frowde, Isuru Gajanayake, Kate Green, Emma Holmes, Alenka Hrovat, Anne‐Katherine Jasensky, Bryn A Jones, Vasiliki Lantzaki, Eve JY Lo, Kirsty MacDonald, Kevin O'Brien, Alejandro Suárez‐Bonnet, Nele Van den Steen, Balazs Szladovits, Annelies Willems, Helen Wilson |
| المصدر: | Journal of Veterinary Internal Medicine, Vol 37, Iss 1, Pp 126-132 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Veterinary medicine |
| مصطلحات موضوعية: | aplastic anemia, neutropenia, T‐2/HT‐2 mycotoxin, thrombocytopenia, trichothecenes, Veterinary medicine, SF600-1100 |
| الوصف: | Abstract Background After a strong epidemiological link to diet was established in an outbreak of pancytopenia in cats in spring 2021 in the United Kingdom, 3 dry diets were recalled. Concentrations of the hemato‐ and myelotoxic mycotoxins T‐2, HT‐2 and diacetoxyscirpenol (DAS) greater than the European Commission guidance for dry cat foods were detected in the recalled diets. Objectives To describe clinical and clinicopathological findings in cats diagnosed with suspected diet induced pancytopenia. Animals Fifty cats presenting with pancytopenia after exposure to a recalled diet. Methods Multicenter retrospective case series study. Cats with known exposure to 1 of the recalled diets were included if presented with bi‐ or pancytopenia and underwent bone marrow examination. Results Case fatality rate was 78%. Bone marrow aspirates and biopsy examination results were available in 23 cats; 19 cats had a bone marrow aspirate, and 8 cats had a biopsy core, available for examination. Bone marrow hypo to aplasia—often affecting all cell lines—was the main feature in all 31 available core specimens. A disproportionately pronounced effect on myeloid and megakaryocytic cells was observed in 19 cats. Myelofibrosis or bone marrow necrosis was not a feature. Conclusion and Clinical Importance Mycotoxin induced pancytopenia should be considered as differential diagnosis in otherwise healthy cats presenting with bi‐ or pancytopenia and bone marrow hypo‐ to aplasia. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1939-1676 0891-6640 |
| Relation: | https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676 |
| DOI: | 10.1111/jvim.16613 |
| URL الوصول: | https://doaj.org/article/a64bb84fc042488c821049f715292e13 |
| رقم الانضمام: | edsdoj.64bb84fc042488c821049f715292e13 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19391676 08916640 |
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| DOI: | 10.1111/jvim.16613 |