التفاصيل البيبلوغرافية
| العنوان: |
A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy |
| المؤلفون: |
Eric J. Hsu, Xuezhi Cao, Benjamin Moon, Joonbeom Bae, Zhichen Sun, Zhida Liu, Yang-Xin Fu |
| المصدر: |
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
| بيانات النشر: |
Nature Portfolio, 2021. |
| سنة النشر: |
2021 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Science |
| الوصف: |
While recognized as the first effective immunotherapy for human cancer, IL-2 based immunotherapy still encounters several limitations in the clinic. Here, the authors design a cytokine receptor-masked IL-2 mutein prodrug that is selectively activated by matrix metalloproteinases in the tumor microenvironment, promoting anti-tumor immune response while minimizing systemic toxicity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-021-22980-w |
| URL الوصول: |
https://doaj.org/article/6463d0ebf5724fa3841e56e2d6aac28f |
| رقم الانضمام: |
edsdoj.6463d0ebf5724fa3841e56e2d6aac28f |
| قاعدة البيانات: |
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