Academic Journal

Mecp2 knock-out astrocytes affect synaptogenesis by interleukin 6 dependent mechanisms

التفاصيل البيبلوغرافية
العنوان: Mecp2 knock-out astrocytes affect synaptogenesis by interleukin 6 dependent mechanisms
المؤلفون: Elena Albizzati, Martina Breccia, Elena Florio, Cecilia Cabasino, Francesca Maddalena Postogna, Riccardo Grassi, Enrica Boda, Cristina Battaglia, Clara De Palma, Concetta De Quattro, Davide Pozzi, Nicoletta Landsberger, Angelisa Frasca
المصدر: iScience, Vol 27, Iss 3, Pp 109296- (2024)
بيانات النشر: Elsevier, 2024.
سنة النشر: 2024
المجموعة: LCC:Science
مصطلحات موضوعية: Cell biology, Immunology, Neuroscience, Omics, Transcriptomics, Science
الوصف: Summary: Synaptic abnormalities are a hallmark of several neurological diseases, and clarification of the underlying mechanisms represents a crucial step toward the development of therapeutic strategies. Rett syndrome (RTT) is a rare neurodevelopmental disorder, mainly affecting females, caused by mutations in the X-linked methyl-CpG-binding protein 2 (MECP2) gene, leading to a deep derangement of synaptic connectivity. Although initial studies supported the exclusive involvement of neurons, recent data have highlighted the pivotal contribution of astrocytes in RTT pathogenesis through non-cell autonomous mechanisms. Since astrocytes regulate synapse formation and functionality by releasing multiple molecules, we investigated the influence of soluble factors secreted by Mecp2 knock-out (KO) astrocytes on synapses. We found that Mecp2 deficiency in astrocytes negatively affects their ability to support synaptogenesis by releasing synaptotoxic molecules. Notably, neuronal inputs from a dysfunctional astrocyte-neuron crosstalk lead KO astrocytes to aberrantly express IL-6, and blocking IL-6 activity prevents synaptic alterations.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2589-0042
Relation: http://www.sciencedirect.com/science/article/pii/S2589004224005170; https://doaj.org/toc/2589-0042
DOI: 10.1016/j.isci.2024.109296
URL الوصول: https://doaj.org/article/6450361ee82f407ab22cd269cc2ed3c1
رقم الانضمام: edsdoj.6450361ee82f407ab22cd269cc2ed3c1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:25890042
DOI:10.1016/j.isci.2024.109296