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Prospective phase II study of preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy - Long-term results

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العنوان: Prospective phase II study of preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy - Long-term results
المؤلفون: Thiede Arnulf, Wehner Daniel, Thalheimer Andreas, Wulf Joern, Guckenberger Matthias, Müller Gottfried, Sailer Marco, Flentje Michael
المصدر: Radiation Oncology, Vol 4, Iss 1, p 67 (2009)
بيانات النشر: BMC, 2009.
سنة النشر: 2009
المجموعة: LCC:Medical physics. Medical radiology. Nuclear medicine
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Abstract Background To evaluate clinical outcome after preoperative short-course radiotherapy for rectal cancer with twice daily fractions of 2.9 Gy to a total dose of 29 Gy and adjuvant chemotherapy for pathological stage UICC ≥ II. Methods 118 patients (median age 64 years; male : female ratio 2.5 : 1) with pathological proven rectal cancer (clinical stage II 50%, III 41.5%, IV 8.5%) were treated preoperatively with twice daily radiotherapy of 2.9 Gy single fraction dose to a total dose of 29 Gy; surgery was performed immediately in the following week with total mesorectal excision (TME). Adjuvant 5-FU based chemotherapy was planned for pathological stage UICC ≥ II. Results After low anterior resection (70%) and abdominoperineal resection (30%), pathology showed stage UICC I (27.1%), II (25.4%), III (37.3%) and IV (9.3%). Perioperative mortality was 3.4% and perioperative complications were observed in 22.8% of the patients. Adjuvant chemotherapy was given in 75.3% of patients with pathological stage UICC ≥ II. After median follow-up of 46 months, five-year overall survival was 67%, cancer-specific survival 76%, local control 92% and freedom from systemic progression 75%. Late toxicity > grade II was observed in 11% of the patients. Conclusions Preoperative short-course radiotherapy, total mesorectal excision and adjuvant chemotherapy for pathological stage UICC ≥ II achieved excellent local control and favorable survival.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1748-717X
Relation: http://www.ro-journal.com/content/4/1/67; https://doaj.org/toc/1748-717X
DOI: 10.1186/1748-717X-4-67
URL الوصول: https://doaj.org/article/c63fa16c22924ea494119c1773f4b637
رقم الانضمام: edsdoj.63fa16c22924ea494119c1773f4b637
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1748717X
DOI:10.1186/1748-717X-4-67