التفاصيل البيبلوغرافية
| العنوان: |
Association between rs1799724 of TNF- α gene and early onset preeclampsia in Chinese: A pilot study |
| المؤلفون: |
Yujie Wang, Jianheng Bao, Shaofang Hua, Lirong Yin |
| المصدر: |
European Journal of Obstetrics & Gynecology and Reproductive Biology: X, Vol 22, Iss , Pp 100303- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: |
Early-onset preeclampsia, Single nucleotide polymorphism mass spectrometry analysis, Hardy-Weinberg equilibration, Linkage disequilibrium, Gynecology and obstetrics, RG1-991 |
| الوصف: |
Objective: To investigate the association between polymorphisms of TNF- α (rs1799724, rs1800629), VEGF (rs3025039) and VEGFR1 (rs 722503) and early onset preeclampsia (EOPE) in Chinese. Methods: A total of 132 EOPE patients from January 2016 to December 2018 at the Second Hospital of Tianjin Medical University were selected as the EOPE group, and 156 normal pregnant patients as the Control group. In both groups, 5 ml of peripheral venous blood was obtained after admission. The characteristics of genotype and allele distribution at the four SNPs in the study subjects were examined by matrix-assisted laser desorption ionization time-of-flight mass spectrometric genotyping. Results: The genotype frequency distribution and allele frequency distribution of rs1799724 were significantly different between the EOPE group and the Control group (P = 0.002，P = 0.003). The T allele was statistically associated with the development of EOPE under a dominant genetic model (P = 0.001). The genotype and allele frequency distributions of rs1800629, rs3025039, and rs 722503 did not differ significantly between the EOPE group and the Control group (P > 0.05). There was no linkage disequilibrium among rs1799724, rs1800629 and rs3025039 loci, the corresponding haploid cannot be formed. Conclusions: The rs1799724 of TNF- α gene is a genetic susceptibility locus for EOPE and may be a potential predictors of preeclampsia. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2590-1613 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2590161324000231; https://doaj.org/toc/2590-1613 |
| DOI: |
10.1016/j.eurox.2024.100303 |
| URL الوصول: |
https://doaj.org/article/63d7bcef541d408d88be70178794b344 |
| رقم الانضمام: |
edsdoj.63d7bcef541d408d88be70178794b344 |
| قاعدة البيانات: |
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