Academic Journal
Helicobacter pylori components increase the severity of metabolic syndrome and its hepatic manifestations induced by a high fat diet
| العنوان: | Helicobacter pylori components increase the severity of metabolic syndrome and its hepatic manifestations induced by a high fat diet |
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| المؤلفون: | Agata Tomaszewska, Weronika Gonciarz, Tomasz Rechcinski, Magdalena Chmiela, Anna K. Kurdowska, Agnieszka Krupa |
| المصدر: | Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024) |
| بيانات النشر: | Nature Portfolio, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Atherosclerosis, Metabolic syndrome, Helicobacter pylori, Endothelium, Medicine, Science |
| الوصف: | Abstract The metabolic syndrome, often accompanied by hepatic manifestations, is a high-risk factor for developing cardiovascular disease. Patients with metabolic dysfunction associated with steatohepatic disease (MASDL) are at significant risk of developing coronary artery disease. Atherosclerosis is a systemic inflammatory disorder in which several factors, including dietary or infectious factors, can cause an inflammatory response. Helicobacter pylori (HP) bacteria have been implicated in the progression of proatherogenic vascular endothelial lesions, moreover, our previous study in an experimental in vivo model of Cavia porcellus showed that HP components and high-fat substances acted synergistically in promoting vascular endothelial inflammation, leading to an early onset of a proatherogenic environment. In the present study, our goal was to determine the contribution of HP components to the development of hepatic manifestations of metabolic syndrome in an experimental model. Our results showed that HP infection in animals exposed to a high-fat diet increased oxidative stress and lipid peroxidation, followed by endothelial lipid deposition, impaired endothelial apoptosis, cell lysis, and increased vascular stiffness. Finally, histopathological analysis of liver tissue showed signs of MASLD development in HP-infected animals fed a high-fat diet. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-024-56308-7 |
| URL الوصول: | https://doaj.org/article/63c6095a8b764872ad5a2e7ba3aee6cb |
| رقم الانضمام: | edsdoj.63c6095a8b764872ad5a2e7ba3aee6cb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-024-56308-7 |