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Preparation and evaluation of injectable Rasagiline mesylate dual-controlled drug delivery system for the treatment of Parkinson’s disease

التفاصيل البيبلوغرافية
العنوان: Preparation and evaluation of injectable Rasagiline mesylate dual-controlled drug delivery system for the treatment of Parkinson’s disease
المؤلفون: Ying Jiang, Xuemei Zhang, Hongjie Mu, Hongchen Hua, Dongyu Duan, Xiuju Yan, Yiyun Wang, Qingqing Meng, Xiaoyan Lu, Aiping Wang, Wanhui Liu, Youxin Li, Kaoxiang Sun
المصدر: Drug Delivery, Vol 25, Iss 1, Pp 143-152 (2018)
بيانات النشر: Taylor & Francis Group, 2018.
سنة النشر: 2018
المجموعة: LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: sustained release, in situ forming implant, microspheres, water-soluble drug, mao-b inhibitor, Therapeutics. Pharmacology, RM1-950
الوصف: A microsphere–gel in situ forming implant (MS–Gel ISFI) dual-controlled drug delivery system was applied to a high water-soluble small-molecule compound Rasagiline mesylate (RM) for effective treatment of Parkinson’s disease. This injectable complex depot system combined an in situ phase transition gel with high drug-loading and encapsulation efficiency RM–MS prepared by a modified emulsion-phase separation method and optimized by Box–Behnken design. It was evaluated for in vitro drug release, in vivo pharmacokinetics, and in vivo pharmacodynamics. We found that the RM-MS-Gel ISFI system showed no initial burst release and had a long period of in vitro drug release (60 days). An in vivo pharmacokinetic study indicated a significant reduction (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1071-7544
1521-0464
10717544
Relation: https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464
DOI: 10.1080/10717544.2017.1419514
URL الوصول: https://doaj.org/article/63bffde498054c508b9ff68888de9403
رقم الانضمام: edsdoj.63bffde498054c508b9ff68888de9403
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:10717544
15210464
DOI:10.1080/10717544.2017.1419514