Academic Journal
Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide
| العنوان: | Nonmyeloablative, HLA-haploidentical bone marrow transplantation with high dose, post-transplantation cyclophosphamide |
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| المؤلفون: | Ashley Munchel, Chimen Kesserwan, Heather J. Symons, Leo Luznik, Yvette L. Kasamon, Richard J. Jones, Ephraim J. Fuchs |
| المصدر: | Pediatric Reports, Pp e15-e15 (2011) |
| بيانات النشر: | MDPI AG, 2011. |
| سنة النشر: | 2011 |
| المجموعة: | LCC:Medicine LCC:Pediatrics |
| مصطلحات موضوعية: | Medicine, Pediatrics, RJ1-570 |
| الوصف: | Allogeneic stem cell transplantation (SCT) from an HLA-haploidentical relative provides a potentially curative treatment option for hematologic malignancies patients who lack a suitably HLA-matched donor. The greatest challenge to performing HLA-haploidentical SCT has been high rates of graft failure and severe graft-versus-host disease (GVHD). Our group has been exploring high dose, post-transplantation cyclophosphamide (Cy) as prophylaxis of GVHD after nonmyeloablative, HLA-haploidentical bone marrow transplantation, or mini-haploBMT. Among 210 recipients of mini-haploBMT, 87% of patients have experienced sustained donor cell engraftment. The cumulative incidences of grades II-IV acute GVHD and chronic GVHD are 27% and 13%, respectively. Five-year cumulative incidence of non-relapse mortality is 18%, relapse is 55%, and actuarial overall survival and event-free survivals are 35% and 27%, respectively. These outcomes suggest that mini-haploBMT with post-transplantation Cy is associated with acceptably low toxicities and can provide longterm survival, if not cure, for many patients with advanced hematologic malignancies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2036-749X 2036-7503 |
| Relation: | https://www.pagepress.org/journals/index.php/pr/article/view/2833; https://doaj.org/toc/2036-749X; https://doaj.org/toc/2036-7503 |
| DOI: | 10.4081/pr.2011.s2.e15 |
| URL الوصول: | https://doaj.org/article/63844e4d3d1742acba8ee8d340994309 |
| رقم الانضمام: | edsdoj.63844e4d3d1742acba8ee8d340994309 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2036749X 20367503 |
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| DOI: | 10.4081/pr.2011.s2.e15 |