Academic Journal
Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults
| العنوان: | Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults |
|---|---|
| المؤلفون: | Jenna N. Adams, Freddie Márquez, Myra S. Larson, John T. Janecek, Blake A. Miranda, Jessica A. Noche, Lisa Taylor, Martina K. Hollearn, Liv McMillan, David B. Keator, Elizabeth Head, Robert A. Rissman, Michael A. Yassa |
| المصدر: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 15, Iss 2, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurology. Diseases of the nervous system LCC:Geriatrics |
| مصطلحات موضوعية: | Alzheimer's disease, amyloid‐beta, medial temporal lobe, memory, neurodegeneration, tau, Neurology. Diseases of the nervous system, RC346-429, Geriatrics, RC952-954.6 |
| الوصف: | Abstract Introduction We tested whether Alzheimer's disease (AD) pathology predicts memory deficits in non‐demented older adults through its effects on medial temporal lobe (MTL) subregional volume. Methods Thirty‐two, non‐demented older adults with cerebrospinal fluid (CSF) (amyloid‐beta [Aβ]42/Aβ40, phosphorylated tau [p‐tau]181, total tau [t‐tau]), positron emission tomography (PET; 18F‐florbetapir), high‐resolution structural magnetic resonance imaging (MRI), and neuropsychological assessment were analyzed. We examined relationships between biomarkers and a highly granular measure of memory consolidation, retroactive interference (RI). Results Biomarkers of AD pathology were related to RI. Dentate gyrus (DG) and CA3 volume were uniquely associated with RI, whereas CA1 and BA35 volume were related to both RI and overall memory recall. AD pathology was associated with reduced BA35, CA1, and subiculum volume. DG volume and Aβ were independently associated with RI, whereas CA1 volume mediated the relationship between AD pathology and RI. Discussion Integrity of distinct hippocampal subfields demonstrate differential relationships with pathology and memory function, indicating specificity in vulnerability and contribution to different memory processes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-8729 |
| Relation: | https://doaj.org/toc/2352-8729 |
| DOI: | 10.1002/dad2.12419 |
| URL الوصول: | https://doaj.org/article/63544acbb62d4127b59ca31494bb0f25 |
| رقم الانضمام: | edsdoj.63544acbb62d4127b59ca31494bb0f25 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23528729 |
|---|---|
| DOI: | 10.1002/dad2.12419 |