Academic Journal
Green-synthesized nanoparticles of the polyherbal extract attenuate the necrosis of pancreatic β-cell in a streptozotocin-induced diabetic model
| العنوان: | Green-synthesized nanoparticles of the polyherbal extract attenuate the necrosis of pancreatic β-cell in a streptozotocin-induced diabetic model |
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| المؤلفون: | Muhammad Abid Hasan Chowdhury, Salahuddin Quader Al Araby, Walla Alelwani, Shahad W. Kattan, Omniah A. Mansouri, Mohammad Rasib Uddin Rahat, Mala Khan, Jitbanjong Tangpong, Md. Atiar Rahman |
| المصدر: | Heliyon, Vol 9, Iss 5, Pp e16137- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Antihyperglycemic polyherbal, Antioxidant, Green-synthesized nanoparticle, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Plant-based nanoformulation is one of the novel approaches for therapeutic benefits. This research synthesized a silver nanoparticle from the polyherbal combination of four plants/seeds (Momordica charantia, Trigonella foenum-graecum, Nigella sativa, and Ocimum sanctum) and investigated its antidiabetic effects in streptozotocin-induced Wistar albino rat model. The polyherbal extract (PH) was extracted by the Soxhlet-solvent extraction method and the resulting crude extract was undergone for silver nanoparticle synthesis. The PH extract was subjected to a four-week intervention in fructose-fed streptozotocin-induced Wistar Albino rats’ models and in vitro antioxidative tests. Experimental animals (age: 6–7 weeks, male, body weight: 200–220 g), were divided into five groups including normal control (NC), reference control (RC), diabetic control (DC), and treatment groups PH200, PH100, and PHAgNP20. After three weeks of intervention, body weight, weekly blood glucose level, oral glucose tolerance test, AST, ALT, alkaline phosphatase, total cholesterol, triglycerides, uric acid, urea, and creatinine level of PH200 were found to be significantly (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023033443; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e16137 |
| URL الوصول: | https://doaj.org/article/6350ad1f1e2a49d0ba6d8910192b3a8b |
| رقم الانضمام: | edsdoj.6350ad1f1e2a49d0ba6d8910192b3a8b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e16137 |