التفاصيل البيبلوغرافية
| العنوان: |
Genetic and molecular mechanisms of hydrocephalus |
| المؤلفون: |
Xuehai Deng, Yiqian Chen, Qiyue Duan, Jianlin Ding, Zhong Wang, Junchi Wang, Xinlong Chen, Liangxue Zhou, Long Zhao |
| المصدر: |
Frontiers in Molecular Neuroscience, Vol 17 (2025) |
| بيانات النشر: |
Frontiers Media S.A., 2025. |
| سنة النشر: |
2025 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
hydrocephalus, genetic abnormality, animal model, molecular changes, cerebrospinal fluid, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
Hydrocephalus is a neurological condition caused by aberrant circulation and/or obstructed cerebrospinal fluid (CSF) flow after cerebral ventricle abnormal dilatation. In the past 50 years, the diagnosis and treatment of hydrocephalus have remained understudied and underreported, and little progress has been made with respect to prevention or treatment. Further research on the pathogenesis of hydrocephalus is essential for developing new diagnostic, preventive, and therapeutic strategies. Various genetic and molecular abnormalities contribute to the mechanisms of hydrocephalus, including gene deletions or mutations, the activation of cellular inflammatory signaling pathways, alterations in water channel proteins, and disruptions in iron metabolism. Several studies have demonstrated that modulating the expression of key proteins, including TGF-β, VEGF, Wnt, AQP, NF-κB, and NKCC, can significantly influence the onset and progression of hydrocephalus. This review summarizes and discusses key mechanisms that may be involved in the pathogenesis of hydrocephalus at both the genetic and molecular levels. While obstructive hydrocephalus can often be addressed by removing the obstruction, most cases require treatment strategies that involve merely slowing disease progression by correcting CSF circulation patterns. There have been few new research breakthroughs in the prevention and treatment of hydrocephalus. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1662-5099 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnmol.2024.1512455/full; https://doaj.org/toc/1662-5099 |
| DOI: |
10.3389/fnmol.2024.1512455 |
| URL الوصول: |
https://doaj.org/article/631662c295d94f30a4a83f480ef0f7fa |
| رقم الانضمام: |
edsdoj.631662c295d94f30a4a83f480ef0f7fa |
| قاعدة البيانات: |
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