التفاصيل البيبلوغرافية
| العنوان: |
Immunogenicity and Protective Efficacy of Aerosolized Live-Attenuated Yellow Fever 17D Vaccine in Mice |
| المؤلفون: |
Feng Zhu, Meng-Xu Sun, Suo-Qun Zhao, Cheng-Feng Qin, Jin-Hua Wang, Yong-Qiang Deng |
| المصدر: |
Vaccines, Vol 12, Iss 8, p 856 (2024) |
| بيانات النشر: |
MDPI AG, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Medicine |
| مصطلحات موضوعية: |
yellow fever virus, aerosol, immunization route, immunogenicity, protective efficacy, Medicine |
| الوصف: |
Yellow fever (YF), caused by the yellow fever virus (YFV), continually spreads and causes epidemics worldwide, posing a great threat to human health. The live-attenuated YF 17D vaccine (YF-17D) has been licensed for preventing YFV infection and administrated via the intramuscular (i.m.) route. In this study, we sought to determine the immunogenicity and protective efficacy of aerosolized YF-17D via the intratracheal (i.t.) route in mice. YF-17D stocks in liquids were successfully aerosolized into particles of 6 μm. Further in vitro phenotype results showed the aerosolization process did not abolish the infectivity of YF-17D. Meanwhile, a single i.t. immunization with aerosolized YF-17D induced robust humoral and cellular immune responses in A129 mice, which is comparable to that received i.p. immunization. Notably, the aerosolized YF-17D also triggered specific secretory IgA (SIgA) production in bronchoalveolar lavage. Additionally, all immunized animals survived a lethal dose of YFV challenge in mice. In conclusion, our results support further development of aerosolized YF-17D in the future. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2076-393X |
| Relation: |
https://www.mdpi.com/2076-393X/12/8/856; https://doaj.org/toc/2076-393X |
| DOI: |
10.3390/vaccines12080856 |
| URL الوصول: |
https://doaj.org/article/62b2cac2c95747d88f0f34427d99000e |
| رقم الانضمام: |
edsdoj.62b2cac2c95747d88f0f34427d99000e |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder