Academic Journal
Prescribers and patients drive maintenance therapy patterns in a community oncology practice: National guidelines versus the real-world experience
| العنوان: | Prescribers and patients drive maintenance therapy patterns in a community oncology practice: National guidelines versus the real-world experience |
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| المؤلفون: | Dana M. Chase, Laura Iadeluca, Jonathan Lim, Wan-Yu Tseng, Purva Bulsara, Gregory Patton |
| المصدر: | Gynecologic Oncology Reports, Vol 54, Iss , Pp 101440- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Gynecology and obstetrics LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Bevacizumab, Maintenance therapy, Ovarian cancer, PARPi, Platinum-based chemotherapy, Gynecology and obstetrics, RG1-991, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Objective: Previous studies have shown that first-line (1L) maintenance therapy (MT) with poly(ADP-ribose) polymerase inhibitors and/or bevacizumab improves outcomes among patients with advanced ovarian cancer (OC); however, these treatments are underutilized. This study aimed to provide a real-world understanding of MTs among patients with advanced OC who received 1L platinum-based chemotherapy (PBC). Methods: A retrospective chart review using iKnowMed electronic health records to identify patients aged ≥18 years with advanced OC who initiated 1L PBC between January 1, 2018–December 31, 2020. Following 1L PBC, patients could have received MT or active surveillance (AS). Kaplan–Meier methods were used to estimate time to treatment discontinuation (TTD), real-world progression-free survival (rwPFS), and overall survival (OS). Results: Of the 600 chart-reviewed patients included, 239 (39.8 %) received MT and 315 (52.5 %) received AS. Patients who were |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2352-5789 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S235257892400119X; https://doaj.org/toc/2352-5789 |
| DOI: | 10.1016/j.gore.2024.101440 |
| URL الوصول: | https://doaj.org/article/62aca536a8d045baba07fd6e15b603ae |
| رقم الانضمام: | edsdoj.62aca536a8d045baba07fd6e15b603ae |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23525789 |
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| DOI: | 10.1016/j.gore.2024.101440 |