التفاصيل البيبلوغرافية
| العنوان: |
Systematic identification of therapeutic targets for coronary artery calcification: an integrated transcriptomic and proteomic Mendelian randomization |
| المؤلفون: |
Lihong Chen, Xiaoqi Ye, Yan Li, Xingwu Ran |
| المصدر: |
Frontiers in Cardiovascular Medicine, Vol 11 (2024) |
| بيانات النشر: |
Frontiers Media S.A., 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| مصطلحات موضوعية: |
coronary artery calcification, Mendelian randomization, target identification, genetic epidemiological study, vascular calcification, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| الوصف: |
BackgroundCoronary artery calcification (CAC) is associated with an increased risk of mortality and cardiovascular events. However, none therapeutic drugs have been proven effective for CAC treatment. The objective of this study was to identify potential therapeutic targets for CAC through the utilization of Mendelian randomization (MR) and colocalization analysis.MethodsThe expression quantitative trait loci (eQTLs) of 16,943 genes from the eQTLGen consortium and protein quantitative trait loci (pQTLs) of 4,412 proteins from a plasma proteome were utilized as genetic instruments. Genetic associations with CAC were derived from a GWAS meta-analysis of 26,909 individuals. The MR and colocalization analysis were utilized to identify potential target genes.ResultsA total of 671 genes were found to be significantly associated with the risk of CAC based on transcriptomic MR analysis at a false discovery rate |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2297-055X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fcvm.2024.1419440/full; https://doaj.org/toc/2297-055X |
| DOI: |
10.3389/fcvm.2024.1419440 |
| URL الوصول: |
https://doaj.org/article/62ac5ea476c048e3b998560f48b29cf4 |
| رقم الانضمام: |
edsdoj.62ac5ea476c048e3b998560f48b29cf4 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder