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From decision to action: Detailed modelling of frog tadpoles reveals neuronal mechanisms of decision-making and reproduces unpredictable swimming movements in response to sensory signals.

التفاصيل البيبلوغرافية
العنوان: From decision to action: Detailed modelling of frog tadpoles reveals neuronal mechanisms of decision-making and reproduces unpredictable swimming movements in response to sensory signals.
المؤلفون: Andrea Ferrario, Andrey Palyanov, Stella Koutsikou, Wenchang Li, Steve Soffe, Alan Roberts, Roman Borisyuk
المصدر: PLoS Computational Biology, Vol 17, Iss 12, p e1009654 (2021)
بيانات النشر: Public Library of Science (PLoS), 2021.
سنة النشر: 2021
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Biology (General), QH301-705.5
الوصف: How does the brain process sensory stimuli, and decide whether to initiate locomotor behaviour? To investigate this question we develop two whole body computer models of a tadpole. The "Central Nervous System" (CNS) model uses evidence from whole-cell recording to define 2300 neurons in 12 classes to study how sensory signals from the skin initiate and stop swimming. In response to skin stimulation, it generates realistic sensory pathway spiking and shows how hindbrain sensory memory populations on each side can compete to initiate reticulospinal neuron firing and start swimming. The 3-D "Virtual Tadpole" (VT) biomechanical model with realistic muscle innervation, body flexion, body-water interaction, and movement is then used to evaluate if motor nerve outputs from the CNS model can produce swimming-like movements in a volume of "water". We find that the whole tadpole VT model generates reliable and realistic swimming. Combining these two models opens new perspectives for experiments.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1553-734X
1553-7358
Relation: https://doaj.org/toc/1553-734X; https://doaj.org/toc/1553-7358
DOI: 10.1371/journal.pcbi.1009654
URL الوصول: https://doaj.org/article/c626504bf072483397086c6e92a0d8f5
رقم الانضمام: edsdoj.626504bf072483397086c6e92a0d8f5
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1553734X
15537358
DOI:10.1371/journal.pcbi.1009654