Academic Journal
Antimicrobial and Anti-Inflammatory Potential of Euphorbia paralias (L.): a bioprospecting study with phytoconstituents analysis
| العنوان: | Antimicrobial and Anti-Inflammatory Potential of Euphorbia paralias (L.): a bioprospecting study with phytoconstituents analysis |
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| المؤلفون: | Ahmed Mohamed Mohamed Youssef, Thabet Hasan Ahmad Althneibat, Doaa Ahmed Mohamed Maaty, Yasser Gaber |
| المصدر: | Journal of Pharmacopuncture, Vol 27, Iss 3, Pp 223-233 (2024) |
| بيانات النشر: | Korean Pharmacopuncture Institute, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Miscellaneous systems and treatments LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | euphorbia paralias, euphorbiaceae, phytochemical analysis, anti-inflammatory, antimicrobial, Medicine, Miscellaneous systems and treatments, RZ409.7-999, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Objectives: The phytochemicals in the aerial parts of Euphorbia paralias (also known as Sea Spurge) and their anti-inflammatory and antimicrobial activities were investigated.Methods: The methanolic extract was characterized using GC-MS and HPLC techniques. The anti-inflammatory feature was estimated through a Human Red Blood Cell (HRBC) membrane stabilization technique, while the antimicrobial feature was evaluated by the disc diffusion agar technique, minimum bactericidal concentration, and minimum inhibitory concentration (MIC) via micro-broth dilution method.Results: The GC/MS results demonstrated the existence of various phytochemicals, such as n-hexadecenoic acid, cis-11-eicosenoic acid, and methyl stearate, recognized for their anti-inflammatory and antibacterial features. The similarity of the phytochemical composition with other Euphorbia species emphasizes the genus-wide similarity. The antiinflammatory activity exhibited a noteworthy inhibitory effect comparable to the reference drug indomethacin. The extract’s antimicrobial potential was tested against a range of microorganisms, demonstrating significant action against Gram-positive bacteria and Candida albicans . The quantification of total phenolics and flavonoids further supported the therapeutic potential of the extract.Conclusion: The methanolic extract from E. paralias emerges as a successful natural source of important active constituents with potential applications as anti-inflammatory and antimicrobial agents. This research provides a first step to valorize Euphorbia paralias insights as a source of worthwhile phytochemicals that have potential applications in the pharmaceutical industry. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2093-6966 |
| Relation: | http://www.journal-jop.org/journal/view.html?doi=10.3831/KPI.2024.27.3.223; https://doaj.org/toc/2093-6966 |
| DOI: | 10.3831/KPI.2024.27.3.223 |
| URL الوصول: | https://doaj.org/article/623752ed37ea41d6bed28d50a1934c70 |
| رقم الانضمام: | edsdoj.623752ed37ea41d6bed28d50a1934c70 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20936966 |
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| DOI: | 10.3831/KPI.2024.27.3.223 |