التفاصيل البيبلوغرافية
| العنوان: |
Do patients with type 2 diabetes have impaired hip bone microstructure? A study using 3D modeling of hip dual-energy X-ray absorptiometry |
| المؤلفون: |
Esther Ubago-Guisado, Enrique Moratalla-Aranda, Sheila González-Salvatierra, José J. Gil-Cosano, Beatriz García-Fontana, Cristina García-Fontana, Luis Gracia-Marco, Manuel Muñoz-Torres |
| المصدر: |
Frontiers in Endocrinology, Vol 13 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: |
type 2 diabetes mellitus, 3D-DXA, bone modelling, bone remodeling, bone QCT/microCT, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: |
AimPatients with type 2 diabetes (T2DM) have more risk of bone fractures. However, areal bone mineral density (aBMD) by conventional dual-energy x-ray absorptiometry (DXA) is not useful for identifying this risk. This study aims to evaluate 3D-DXA parameters determining the cortical and trabecular compartments in patients with T2DM compared to non-diabetic subjects and to identify their determinants.Materials and methodsCase-control study in 111 T2DM patients (65.4 ± 7.6 years old) and 134 non-diabetic controls (64.7 ± 8.6-year-old). DXA, 3D-DXA modelling via 3D-Shaper software and trabecular bone score (TBS) were used to obtain aBMD, cortical and trabecular parameters, and lumbar spine microarchitecture, respectively. In addition, biochemical markers as 25-hydroxyvitamin d, type I procollagen N-terminal propeptide (P1NP), C-terminal telopeptide of type I collagen (CTX), and glycated haemoglobin (HbA1c) were analysed.ResultsMean-adjusted values showed higher aBMD (5.4%-7.7%, ES: 0.33-0.53) and 3D-DXA parameters (4.1%-10.3%, ES: 0.42-0.68) in the T2DM group compared with the control group. However, TBS was lower in the T2DM group compared to the control group (-14.7%, ES: 1.18). In addition, sex (β = 0.272 to 0.316) and body mass index (BMI) (β = 0.236 to 0.455) were the most consistent and positive predictors of aBMD (p ≤ 0.01). BMI and P1NP were negative predictors of TBS (β = -0.530 and -0.254, respectively, p ≤ 0.01), while CTX was a positive one (β = 0.226, p=0.02). Finally, BMI was consistently the strongest positive predictor of 3D-DXA parameters (β = 0.240 to 0.442, p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2022.1069224/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2022.1069224 |
| URL الوصول: |
https://doaj.org/article/622f5d1638b54fd4b9147f8ae08870c5 |
| رقم الانضمام: |
edsdoj.622f5d1638b54fd4b9147f8ae08870c5 |
| قاعدة البيانات: |
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