التفاصيل البيبلوغرافية
| العنوان: |
Symmetric dimethylguanidino valeric acid, a novel single biomarker of hepatic steatosis |
| المؤلفون: |
Roman N. Rodionov, Natalia Jarzebska, Yen Chin Koay, Mengbo Li, Matthias Kuhn, Stefan R. Bornstein, Jens Martens-Lobenhoffer, Mohammad Eslam, Fei Wen Chen, Elena Rubets, Alexander G. Markov, Norbert Weiss, Andreas Birkenfeld, Peter Schwarz, Stefanie M. Bode-Böger, Nikolaos Perakakis, John F. O’Sullivan, Jacob George |
| المصدر: |
iScience, Vol 27, Iss 12, Pp 111366- (2024) |
| بيانات النشر: |
Elsevier, 2024. |
| سنة النشر: |
2024 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Health sciences, Clinical finding, Physiological state, Science |
| الوصف: |
Summary: There is an unmet need for a biomarker of liver fat. We identified dimethylguanidino valeric acid (DMGV) as a circulating biomarker of liver fat. Here, we assess its two isoforms—symmetric (SDGV) and asymmetric (ADGV)—as biomarkers of steatosis. We determined plasma ADGV, SDGV, related metabolites, alanine aminotransferase (ALT), and the fatty liver index (FLI) in two cohorts and compared their diagnostic performance for liver fat detection. SDGV was the strongest predictor of moderate to severe steatosis. Changes in SDGV correlated with changes in liver fat % in a prospective cohort. In a murine model of fatty liver disease, protein levels and activity of alanine:glyoxylate aminotransferase 2 (AGXT2), which produces SDGV, were increased and coincided with elevation of SDGV concentrations. SDGV is a biomarker of liver fat and its increase in hepatic steatosis results from the upregulation of AGXT2 activity. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004224025914; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2024.111366 |
| URL الوصول: |
https://doaj.org/article/61f72615a51146699ca563f9a413a980 |
| رقم الانضمام: |
edsdoj.61f72615a51146699ca563f9a413a980 |
| قاعدة البيانات: |
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