التفاصيل البيبلوغرافية
| العنوان: |
Contribution of preoperative gut microbiota in postoperative neurocognitive dysfunction in elderly patients undergoing orthopedic surgery |
| المؤلفون: |
Jiangjiang Bi, Yifan Xu, Shiyong Li, Gaofeng Zhan, Dongyu Hua, Juan Tan, Xiaohui Chi, Hongbing Xiang, Fengjing Guo, Ailin Luo |
| المصدر: |
Frontiers in Aging Neuroscience, Vol 15 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: |
gut microbiota, metabolites, orthopedic surgery, elderly patients, postoperative neurocognitive dysfunction, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: |
ObjectiveTo investigate the role of gut microbiota and metabolites in POCD in elderly orthopedic patients, and screen the preoperative diagnostic indicators of gut microbiota in elderly POCD.Method40 elderly patients undergoing orthopedic surgery were enrolled and divided into Control group and POCD group following neuropsychological assessments. Gut microbiota was determined by 16S rRNA MiSeq sequencing, and metabolomics of GC–MS and LC–MS was used to screen the differential metabolites. We then analyzed the pathways enriched by metabolites.ResultThere was no difference in alpha or beta diversity between Control group and POCD group. There were significant differences in 39 ASV and 20 genera bacterium in the relative abundance. Significant diagnostic efficiency analyzed by the ROC curves were found in 6 genera bacterium. Differential metabolites in the two groups including acetic acid, arachidic acid, pyrophosphate etc. were screened out and enriched to certain metabolic pathways which impacted the cognition function profoundly.ConclusionGut microbiota disorders exist preoperatively in the elderly POCD patients, by which there could be a chance to predict the susceptible population.Clinical Trial Registration[http://www.chictr.org.cn/edit.aspx?pid=133843&htm=4], identifier [ChiCTR2100051162]. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1663-4365 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fnagi.2023.1108205/full; https://doaj.org/toc/1663-4365 |
| DOI: |
10.3389/fnagi.2023.1108205 |
| URL الوصول: |
https://doaj.org/article/e61ee704a4524d8bbf455c05c8219a23 |
| رقم الانضمام: |
edsdoj.61ee704a4524d8bbf455c05c8219a23 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder