التفاصيل البيبلوغرافية
| العنوان: |
Estrous cycle and gestational age-dependent expression of members of the interleukin-36 subfamily in a semi-allogeneic model of infected and non-infected murine pregnancy |
| المؤلفون: |
José Martin Murrieta Coxca, Fernando Gómez-Chávez, Damariz Adriana Baeza-Martínez, Mario Eugenio Cancino-Díaz, Juan Carlos Cancino-Díaz, Sonia Mayra Pérez-Tapia, Elba Reyes-Maldonado, Sandra Rodríguez-Martínez |
| المصدر: |
Frontiers in Immunology, Vol 7 (2016) |
| بيانات النشر: |
Frontiers Media S.A., 2016. |
| سنة النشر: |
2016 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
Estrous Cycle, Inflammation, Listeria monocytogenes, Pregnancy Complications, Infectious, IL-36, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
The IL-36 subfamily is a recently described group of cytokines with pro-inflammatory behavior, comprising three agonists (α, β and γ), its receptor (R) and one antagonist (Ra). The expression and function of IL-36 subfamily members in the estrous cycle in healthy and infected pregnancy have not been described. We evaluated mRNA and protein expression of IL-36 family members during the estrous cycle, implantation, fetal development and post-labor periods in a model of allogenic pregnancy in mice. We also explored the ability of Listeria monocytogenes to modulate expression of IL-36 subfamily members during pregnancy. Expression of IL-36 subfamily members showed different expression during the estrous cycle and pregnancy, but was induced at estrous, 16.5 days post coitum (dpc), 18.5 dpc and labor. IL-36 subfamily members showed a characteristic distribution in the glandular epithelium, perimetrium, myometrium, and stratum vasculare. Infection with Listeria monocytogenes during pregnancy induced strong production of IL-36 subfamily members, an observation that correlated with an increasing prevalence of fetal loss. Conclusions: IL-36 agonists showed specific patterns of mRNA and protein expression that might suggest functional specialization or specific target cells. Infection with Listeria monocytogenes during pregnancy induced strong production of IL-36 subfamily members. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00376/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2016.00376 |
| URL الوصول: |
https://doaj.org/article/6160af21a88542d88233242e347c33fd |
| رقم الانضمام: |
edsdoj.6160af21a88542d88233242e347c33fd |
| قاعدة البيانات: |
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