التفاصيل البيبلوغرافية
| العنوان: |
Salivary ZG16B expression loss follows exocrine gland dysfunction related to oral chronic graft-versus-host disease |
| المؤلفون: |
Ana Caroline Costa-da-Silva, Marit H. Aure, Joshua Dodge, Daniel Martin, Susan Dhamala, Monica Cho, Jeremy J. Rose, Carol W. Bassim, Kiran Ambatipudi, Frances T. Hakim, Steven Z. Pavletic, Jacqueline W. Mays |
| المصدر: |
iScience, Vol 25, Iss 1, Pp 103592- (2022) |
| بيانات النشر: |
Elsevier, 2022. |
| سنة النشر: |
2022 |
| المجموعة: |
LCC:Science |
| مصطلحات موضوعية: |
Pathophysiology, Proteomics, Transcriptomics, Science |
| الوصف: |
Summary: Chronic graft-versus-host disease (cGVHD) targets include the oral mucosa and salivary glands after allogeneic hematopoietic stem cell transplant (HSCT). Without incisional biopsy, no diagnostic test exists to confirm oral cGVHD. Consequently, therapy is often withheld until severe manifestations develop. This proteomic study examined saliva and human salivary gland for a biomarker profile at first onset of oral cGVHD prior to initiation of topical steroid therapy. Whole saliva collected at onset of biopsy-proven oral GVHD was assessed using liquid chromatography–coupled tandem mass spectrometry with identification of 569 proteins, of which 77 significantly changed in abundance. ZG16B, a secretory lectin protein, was reduced 2-fold in oral cGVHD saliva (p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004221015625; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2021.103592 |
| URL الوصول: |
https://doaj.org/article/615891903b1847178ae5f937acbf9658 |
| رقم الانضمام: |
edsdoj.615891903b1847178ae5f937acbf9658 |
| قاعدة البيانات: |
Directory of Open Access Journals |
Full Text Finder