Academic Journal
Immunomodulatory effect of ashwagandha (Withania somnifera L. Dunal) and its impact on COVID-19
| العنوان: | Immunomodulatory effect of ashwagandha (Withania somnifera L. Dunal) and its impact on COVID-19 |
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| المؤلفون: | Arun M. K. Pushpakaran, Jyoti Singh, Prasad Rasane, Sawinder Kaur, Jaspreet Kaur, Jasjit Kaur, Mukul Kumar, Amine Assouguem |
| المصدر: | Foods and Raw Materials, Vol 13, Iss 1, Pp 46-57 (2025) |
| بيانات النشر: | Kemerovo State University, 2025. |
| سنة النشر: | 2025 |
| المجموعة: | LCC:Food processing and manufacture |
| مصطلحات موضوعية: | ashwagandha, immunity, lymphocytes, natural killer cells, cancer, covid-19, Food processing and manufacture, TP368-456 |
| الوصف: | Ashwagandha (Withania somnifera L. Dunal) is an Ayurvedic medicinal herb that has been known for its therapeutic properties for millennia. Ashwagandha contains several bioactive compounds, including withanolides, alkaloids, and saponins. They make ashwagandha a potent adaptogen and a versatile herb that can maintain optimal health and overall well-being. Ashwagandha reduces stress and anxiety, as well as boosts the immune system. Its anti-inflammatory properties treat arthritis, asthma, diabetes, and inflammatory bowel disease. Ashwagandha produces an immunomodulatory effect on natural killer cells, lymphocytes, and leukemia cells. It enhances the activity of natural killer cells, increases lymphocyte function, and induces apoptosis in leukemia cells. However, its mechanism of action still remains understudied. Ashwagandha has an impact on COVID-19: phytochemical withanone blocks or weakens the interaction between S-protein and Angiotensin-converting enzyme 2. Withanoside V and somniferine inhibit viral transcription and replication caused by SARSCoV-2 Mpro. This review explores the potential utilization of ashwagandha in the food industry, i.e., its safety and toxicity, as well as the mechanism behind its immunomodulatory effect. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2308-4057 2310-9599 |
| Relation: | https://jfrm.ru/en/issues/22431/22447/; https://doaj.org/toc/2308-4057; https://doaj.org/toc/2310-9599 |
| DOI: | 10.21603/2308-4057-2025-1-622 |
| URL الوصول: | https://doaj.org/article/610a4fdd4d2643da88372fba2547132f |
| رقم الانضمام: | edsdoj.610a4fdd4d2643da88372fba2547132f |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 23084057 23109599 |
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| DOI: | 10.21603/2308-4057-2025-1-622 |