التفاصيل البيبلوغرافية
| العنوان: |
Role of mTOR inhibitor in the cellular and humoral immune response to a booster dose of SARS-CoV-2 mRNA-1273 vaccine in kidney transplant recipients |
| المؤلفون: |
Isabel Pérez-Flores, Ignacio Juarez, Arianne S. Aiffil Meneses, Ana Lopez-Gomez, Natividad Calvo Romero, Beatriz Rodriguez-Cubillo, María Angeles Moreno de la Higuera, Belen Peix-Jiménez, Raquel Gonzalez-Garcia, Elvira Baos-Muñoz, Ana Arribi Vilela, Manuel Gómez Del Moral, Eduardo Martínez-Naves, Ana Isabel Sanchez-Fructuoso |
| المصدر: |
Frontiers in Immunology, Vol 14 (2023) |
| بيانات النشر: |
Frontiers Media S.A., 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: |
kidney transplantation, SARS-CoV-2 vaccine, immune response, COVID-19, mTOR, Immunologic diseases. Allergy, RC581-607 |
| الوصف: |
BackgroundImmunocompromised patients have an increased risk of developing severe COVID disease, as well as a tendency to suboptimal responses to vaccines. The objective of this study was to evaluate the specific cellular and humoral adaptive immune responses of a cohort of kidney transplant recipients (KTR) after 3 doses of mRNA-1273 vaccine and to determinate the main factors involved.MethodsProspective observational study in 221 KTR (149 non infected), 55 healthy volunteers (HV) and 23 dialysis patients (DP). We evaluated anti-spike (by quantitative chemiluminescence immunoassay) and anti-nucleocapsid IgG (ELISA), percentage of TCD4+ and TCD8+ lymphocytes producing IFNγ against S-protein by intracellular flow cytometry after Spike-specific 15-mer peptide stimulation and serum neutralizing activity (competitive ELISA) at baseline and after vaccination.ResultsAmong COVID-19 naïve KTR, 54.2% developed cellular and humoral response after the third dose (vs 100% in DP and 91.7% in HV), 18% only showed cell-mediated response, 22.2% exclusively antibody response and 5.6% none. A correlation of neutralizing activity with both the IgG titer (r=0.485, p1000/mm3 [4.68 (1.72-12.73, p=0.003], eGFR>30 mL/min [7.34(2.72-19.84), p |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1111569/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2023.1111569 |
| URL الوصول: |
https://doaj.org/article/61014202c88642b2bd79244bc4d7700b |
| رقم الانضمام: |
edsdoj.61014202c88642b2bd79244bc4d7700b |
| قاعدة البيانات: |
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