Academic Journal
Hyaluronic Acid Inhibits Polycation Induced Cellular Responses
| العنوان: | Hyaluronic Acid Inhibits Polycation Induced Cellular Responses |
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| المؤلفون: | A. lalenti, A. lanaro, G. Brignola, P. Marotta, M. Di Rosa |
| المصدر: | Mediators of Inflammation, Vol 3, Iss 4, Pp 287-289 (1994) |
| بيانات النشر: | Hindawi Limited, 1994. |
| سنة النشر: | 1994 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | Positively charged macromolecules cause a variety of pathological events through their electrostatic interaction with anionic sites present on the membrane of target cells. In the present study we have investigated the effect of hyaluronic acid, a negatively charged molecule, on rat paw oedema induced by poly-L-lysine as well as on histamine release from rat mast cells and nitric oxide formation from rabbit aorta, both induced by this polycation. The results indicate that hyaluronic acid is able to suppress these poly-L-lysine induced effects with a mechanism which possibly depends on its negative charges which may balance the effects of positively charged polycations. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0962-9351 1466-1861 09629351 |
| Relation: | https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861 |
| DOI: | 10.1155/S0962935194000396 |
| URL الوصول: | https://doaj.org/article/e604d156a84a4d3dbdf875d65c11a2f6 |
| رقم الانضمام: | edsdoj.604d156a84a4d3dbdf875d65c11a2f6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09629351 14661861 |
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| DOI: | 10.1155/S0962935194000396 |