التفاصيل البيبلوغرافية
| العنوان: |
BCL7B, a SWI/SNF complex subunit, orchestrates cancer immunity and stemness |
| المؤلفون: |
Sayaka Higuchi, Yuji Suehiro, Luna Izuhara, Sawako Yoshina, Akira Hirasawa, Shohei Mitani |
| المصدر: |
BMC Cancer, Vol 23, Iss 1, Pp 1-14 (2023) |
| بيانات النشر: |
BMC, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: |
BCL7B, SWI/SNF complex, H3K27me3, Recognition centroid sequence changes, Immune system, Cancer stem cells, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: |
Abstract Cancer is one of the main causes of human death. Here, we focus on the B-cell lymphoma 7 protein family member B (BCL7B) gene, an accessory subunit of the SWI/SNF chromatin-remodelling complex. To characterize the function of BCL7B, heterozygous BCL7B-deficient stomach cancer cell lines were generated with the CRISPR/Cas9 genome editing system. The comprehensive gene expression patterns were compared between parental cells and each ΔBCL7B cell line by RNA-seq. The results showed marked downregulation of immune-related genes and upregulation of stemness-related genes in the ΔBCL7B cell lines. Moreover, by ChIP-seq analysis with H3K27me3 antibody, the changes of epigenetic modification sequences were compared between parental cells and each ΔBCL7B cell line. After machine learning, we detected the centroid sequence changes, which exerted an impact on antigen presentation. The regulation of BCL7B expression in cancer cells gives rise to cancer stem cell-like characteristics and the acquisition of an immune evasion phenotype. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
1471-2407 |
| Relation: |
https://doaj.org/toc/1471-2407 |
| DOI: |
10.1186/s12885-023-11321-3 |
| URL الوصول: |
https://doaj.org/article/5fdba5df908a4a818136fbc3c9f40645 |
| رقم الانضمام: |
edsdoj.5fdba5df908a4a818136fbc3c9f40645 |
| قاعدة البيانات: |
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