Academic Journal
Simvastatin Promotes Osteogenesis and Angiogenesis through Mediating Immunology of Senescent Macrophages
| العنوان: | Simvastatin Promotes Osteogenesis and Angiogenesis through Mediating Immunology of Senescent Macrophages |
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| المؤلفون: | Guangping QU, Yuyu ZHAO, Xiaohong YAO, Ruiqiang HANG |
| المصدر: | Taiyuan Ligong Daxue xuebao, Vol 53, Iss 4, Pp 600-611 (2022) |
| بيانات النشر: | Editorial Office of Journal of Taiyuan University of Technology, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Chemical engineering LCC:Materials of engineering and construction. Mechanics of materials LCC:Technology |
| مصطلحات موضوعية: | simvastatin, macrophages, titanium, immune microenvironment, osteogenesis, angiogenesis, Chemical engineering, TP155-156, Materials of engineering and construction. Mechanics of materials, TA401-492, Technology |
| الوصف: | In this article, we mainly investigated the effects of different simvastatin concentrations on the biological behavior of senescent macrophages and the immune microenvironment mediated by them on osteogenic and angiogenic functions. The feasibility of loading simvastatin on titanium surfaces to mediate the function of senescent macrophages was also explored. The results show that when the concentration of the drug was 0.1 μmol/L, it promoted the proliferation of macrophages and polarized them to pro-healing M2 phenotype, which is beneficial for macrophages to create an immune microenvironment promoting osteogenesis and angiogenesis. The chitosan/gelatin coating constructed on titanium surface could load and release simvastatin, promoting the viability and proliferation of senescent macrophages. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Chinese |
| تدمد: | 1007-9432 |
| Relation: | https://tyutjournal.tyut.edu.cn/englishpaper/show-1892.html; https://doaj.org/toc/1007-9432 |
| DOI: | 10.16355/j.cnki.issn1007-9432tyut.2022.04.003 |
| URL الوصول: | https://doaj.org/article/5fb9c80e0d67431985ba95eea49b6f37 |
| رقم الانضمام: | edsdoj.5fb9c80e0d67431985ba95eea49b6f37 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 10079432 |
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| DOI: | 10.16355/j.cnki.issn1007-9432tyut.2022.04.003 |