Academic Journal
Homeostatic Regulation of Interneuron Apoptosis During Cortical Development
| العنوان: | Homeostatic Regulation of Interneuron Apoptosis During Cortical Development |
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| المؤلفون: | Myrto Denaxa, Guilherme Neves, Juan Burrone, Vassilis Pachnis |
| المصدر: | Journal of Experimental Neuroscience, Vol 12 (2018) |
| بيانات النشر: | SAGE Publishing, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | The mammalian cortex consists of two main neuronal types: the principal excitatory pyramidal neurons (PNs) and the inhibitory interneurons (INs). The interplay between these two neuronal populations – which drive excitation and inhibition (E/I balance), respectively – is crucial for controlling the overall activity in the brain. A number of neurological and psychiatric disorders have been associated with changes in E/I balance. It is not surprising, therefore, that neural networks employ several different mechanisms to maintain their firing rates at a stable level, collectively referred as homeostatic forms of plasticity. Here, we share our views on how the size of IN populations may provide an early homeostatic checkpoint for controlling brain activity. In a recent paper published in Cell Reports , we demonstrate that the extent of IN apoptosis during a critical early postnatal period is plastic, cell type specific, and can be reduced in a cell-autonomous manner by acute increases in neuronal activity. We propose that a critical interplay between the physiological state of the network and its cellular units fine-tunes the size of IN populations with the aim of stabilizing network activity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1179-0695 11790695 |
| Relation: | https://doaj.org/toc/1179-0695 |
| DOI: | 10.1177/1179069518784277 |
| URL الوصول: | https://doaj.org/article/5eebdef30a6c4027b1e472f9027c1325 |
| رقم الانضمام: | edsdoj.5eebdef30a6c4027b1e472f9027c1325 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11790695 |
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| DOI: | 10.1177/1179069518784277 |