التفاصيل البيبلوغرافية
| العنوان: |
Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s |
| المؤلفون: |
Misato Irie, Hiroki Kabata, Kotaro Sasahara, Momoko Kurihara, Yoshitaka Shirasaki, Takashi Kamatani, Rie Baba, Masako Matsusaka, Satoshi Koga, Katsunori Masaki, Jun Miyata, Yasutomo Araki, Toru Kikawada, Yasuaki Kabe, Makoto Suematsu, Mai Yamagishi, Sotaro Uemura, Kazuyo Moro, Koichi Fukunaga |
| المصدر: |
Cell Reports, Vol 42, Iss 6, Pp 112610- (2023) |
| بيانات النشر: |
Elsevier, 2023. |
| سنة النشر: |
2023 |
| المجموعة: |
LCC:Biology (General) |
| مصطلحات موضوعية: |
CP: Immunology, CP: Molecular biology, Biology (General), QH301-705.5 |
| الوصف: |
Summary: Group 2 innate lymphoid cells (ILC2s) produce large amounts of type 2 cytokines including interleukin-5 (IL-5) and IL-13 in response to various stimuli, causing allergic and eosinophilic diseases. However, the cell-intrinsic regulatory mechanisms of human ILC2s remain unclear. Here, we analyze human ILC2s derived from different tissues and pathological conditions and identify ANXA1, encoding annexin A1, as a commonly highly expressed gene in non-activated ILC2s. The expression of ANXA1 decreases when ILC2s activate, but it increases autonomously as the activation subsides. Lentiviral vector-based gene transfer experiments show that ANXA1 suppresses the activation of human ILC2s. Mechanistically, ANXA1 regulates the expression of the metallothionein family genes, including MT2A, which modulate intracellular zinc homeostasis. Furthermore, increased intracellular zinc levels play an essential role in the activation of human ILC2s by promoting the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and GATA3 expression. Thus, the ANXA1/MT2A/zinc pathway is identified as a cell-intrinsic metalloregulatory mechanism for human ILC2s. |
| نوع الوثيقة: |
article |
| وصف الملف: |
electronic resource |
| اللغة: |
English |
| تدمد: |
2211-1247 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2211124723006216; https://doaj.org/toc/2211-1247 |
| DOI: |
10.1016/j.celrep.2023.112610 |
| URL الوصول: |
https://doaj.org/article/5ebedb94d6044b70927a7e447e0f351d |
| رقم الانضمام: |
edsdoj.5ebedb94d6044b70927a7e447e0f351d |
| قاعدة البيانات: |
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