Academic Journal
Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children
| العنوان: | Immunogenicity and safety of inactivated chromatographically purified Vero cell-derived Japanese encephalitis vaccine in Thai children |
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| المؤلفون: | Pornthep Chanthavanich, Kriengsak Limkittikul, Chukiat Sirivichayakul, Watcharee Chokejindachai, Weerawan Hattasingh, Krisana Pengsaa, Surachai Surangsrirat, Termsang Srisuwannaporn, Benjawan Kaewma, Sutee Yoksan, Gao Jun, Bai Zhumu |
| المصدر: | Human Vaccines & Immunotherapeutics, Vol 14, Iss 4, Pp 900-905 (2018) |
| بيانات النشر: | Taylor & Francis Group, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Immunologic diseases. Allergy LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | children, chromatographical purify, immunogenicity, inactivated vero cell-derived je vaccine, pediatrics, safety, vaccinology, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Summary: Inactivated mouse-brain-derived Japanese encephalitis vaccine has a worrisome safety profile and the live attenuated vaccine is unsuitable in immunodeficiency. This study aimed to evaluate the immunogenicity and safety of an inactivated chromatographically purified Vero-cell-derived JE vaccine (CVI-JE, Beijing P-3 strain) in children. 152 healthy Thai children, with an average (SD) age of 14.4 (3.8) months, received 3 doses of CVI-JE on days 0, 7–28, and one year. Homologous JE neutralizing antibody titers (NT) were measured. All subjects had seroprotection [geometric mean titer (GMT) 150] 28 days' post 2nd vaccination. The seroprotection rates at 1 year after primary series and and 1 month after the booster were 89.3% (GMT 49) and 100% (GMT 621), respectively. Local and systemic reactions–fever (17.6%), vomiting (8%), and poor appetite (5.3%)–were noted within 28 days' post-vaccination. All these symptoms were self-limited. Conclusions: CVI-JE is safe, immunogenic, and provided high NT. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2164-5515 2164-554X 21645515 |
| Relation: | https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X |
| DOI: | 10.1080/21645515.2017.1414763 |
| URL الوصول: | https://doaj.org/article/a5e971c1634845c783bc3cdb25f2fa10 |
| رقم الانضمام: | edsdoj.5e971c1634845c783bc3cdb25f2fa10 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21645515 2164554X |
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| DOI: | 10.1080/21645515.2017.1414763 |